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The relationship between periprocedural myocardial infarction and subsequent target vessel revascularization following percutaneous coronary revascularization

Insights from the EPIC trial

Craig R. Narins, MD^*, Dave P. Miller, MS^*, Robert M. Califf, MD and Eric J. Topol, MD^*

^* Department of Cardiology and the Joseph J. Jacobs Center for Vascular Biology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
Duke University Clinical Research Institute, Durham, North Carolina, USA

View larger version (13K): [in a new window]   Figure 1 Incidence of postintervention myocardial infarction based on various CK cut points.

View larger version (18K): [in a new window]   Figure 2 Incidence of late death or target vessel revascularization as a function of the postintervention CK ratio.

View larger version (14K): [in a new window]   Figure 3 Odds ratios (with 95% CI) delineating the risk of late target vessel revascularization for various magnitudes of CK elevation.

View larger version (16K): [in a new window]   Figure 4 Kaplan-Meier estimates of late target revascularization among patients who were revascularization free at 30 days by enzyme ratio, using CK ratios of >1 (A); >3 (B); >5 (C); and >10 (D).