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Effect of angiotensin converting enzyme inhibition on sudden cardiac death in patients following acute myocardial infarction

A meta-analysis of randomized clinical trials

Michael J. Domanski, MD, FACC^a, Derek V. Exner, MD^a,1, Craig B. Borkowf, PhD, Nancy L. Geller, PhD, Yves Rosenberg, MD, MPH^a and Marc A. Pfeffer, MD, PhD, FACC^#

^a Clinical Trials Group, National Heart, Lung and Blood Institute, Bethesda, Maryland, USA
Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, Maryland, USA
^# Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

View larger version (21K): [in a new window]   Figure 1 Odds ratios (OR) and their 95% confidence intervals (CI) for the endpoint of sudden cardiac death (SCD) in each of the 15 individual trials. The overall OR for SCD in patients randomized to ACE inhibitor therapy was 0.80 (95% CI 0.70 to 0.92). Results are shown on a log scale with box width proportional to the sample size.