Relationship between endothelin-1 extraction in the peripheral circulation and systemic vascular resistance in patients with severe congestive heart failure
Takayoshi Tsutamoto, MDa,
Atsuyuki Wada, MDa,
Tomoko Hisanaga, MDa,
Keiko Maeda, MDa,
Masato Ohnishi, MDa,
Naoko Mabuchi, MDa,
Masahide Sawaki, MDa,
Masaru Hayashi, MDa,
Masanori Fujii, MDa and
Masahiko Kinoshita, MDa
a First Department of Internal Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu 520-2192, Japan
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Figure 1 Plasma levels of endothelin-1 (ET-1) in age-matched normal subjects and in patients with congestive heart failure. FA = femoral artery; FV = femoral vein. Closed columns represent the ET-1 level in FA and open columns represent the ET-1 level in FV. *p < 0.01, **p < 0.001 vs. the value of the ET-1 level in FA. #p < 0.05 vs. the value of the ET-1 level of NYHA functional class II patients. ##p < 0.0001 vs. the value of the ET-1 level of NYHA functional class II or class III patients with ANOVA by the Scheffé F test.
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Figure 2 Plasma endothelin-1 (ET-1) spillover in the leg in age-matched normal subjects and in patients with congestive heart failure. Plasma ET-1 spillover in the leg = ET-1 in femoral vein – ET-1 in femoral artery. *p < 0.0001 vs. the value of NYHA class II. #p < 0.0001 vs. the value of NYHA class III with ANOVA by the Scheffé F test.
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Figure 3 Relationship between the plasma arterial endothelin-1 (ET-1) level and plasma ET-1 extraction in the lower limb and systemic vascular resistance (SVR) in NYHA functional class IV patients. Plasma ET-1 extraction in the leg = ET-1 in femoral artery –ET-1 in femoral vein.
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Figure 4 Correlation between the plasma arterial endothelin-1 (ET-1) level and plasma ET-1 extraction in the peripheral circulation in patients with congestive heart failure. Plasma ET-1 extraction in the peripheral circulation = ET-1 in femoral artery – ET-1 in femoral vein.
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Figure 5 Plasma levels of endothelin-1 (ET-1) of femoral artery (FA) and femoral vein (FV) and plasma ET-1 extraction in leg before and after the treatments with angiotensin-converting enzyme inhibitors (ACEI). *p < 0.01 vs. the value of ET-1 in FA. Plasma ET-1 extraction in the leg = ET-1 in femoral artery – ET-1 in femoral vein.
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