Fatal cardiac rupture among patients treated with thrombolytic agents and adjunctive thrombin antagonists
Observations from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction 9 Study
Richard C. Becker, MD*,
Judith S. Hochman, MD ,
Christopher P. Cannon, MD ,
Frederick A. Spencer, MD*,
Steven P. Ball, RN*,
Michael J. Rizzo ,
Elliott M. Antman, MD for the TIMI 9 Investigators
* Cardiovascular Thrombosis Research Center, University of Massachusetts Medical School, Worcester, Massachusetts, USA
St. Luke’s/Roosevelt Hospital Center, Columbia University, College of Physicians and Surgeons, New York, New York, USA
Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
TIMI Database and Coordinating Center, Veterans Administration Medical Center, West Roxbury, Massachusetts, USA
View larger version (12K):
[in a new window]
|
Figure 1 Multivariable analysis of patients experiencing cardiac rupture or electromechanical dissociation (EMD) identified age  70 years, female gender and prior angina as independent predictors of an in-hospital event.
|
|
View larger version (13K):
[in a new window]
|
Figure 2 Multivariable analysis of patients with non–rupture-related death. Female gender was not independently associated with non–cardiac rupture death.
|
|
View larger version (17K):
[in a new window]
|
Figure 3 Serial coagulation measurements (activated partial thromboplastin times [aPTT]) for patients with and without cardiac rupture–related death and those surviving to hospital discharge. There were no differences in the intensity of anticoagulation at the 12-, 24-, 48- and 72-h sampling time points.
|
|
|
