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Gender differences in myocardial blood flow dynamics

Lipid profile and hemodynamic effects

Claire S. Duvernoy, MD^a, Christian Meyer, MD^a, Vanadin Seifert-Klauss, MD^*, Firat Dayanikli, MD, Ichiro Matsunari, MD^a, Judith Rattenhuber^*, Cornelia Höss, MD^*, Henner Graeff, MD^* and Markus Schwaiger, MD, FACC^a

^a Nuklearmedizinische Klinik und Poliklinik, Munich, Germany
^* Frauenklinik, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany
Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA

View larger version (18K): [in a new window]   Figure 1 Myocardial blood flow (MBF) at rest and during adenosine hyperemia is plotted for women vs. men. Both groups show a significant rise in MBF during hyperemia, whereas values for women are significantly higher both at rest and during adenosine stress.

View larger version (20K): [in a new window]   Figure 2 Correlations between stress myocardial blood flow (MBF) and lipid parameters HDL, triglycerides, and cholesterol/HDL ratio are plotted. Correlation coefficients and p values are as shown. To convert lipid values to millimoles per liter, multiply by 0.02586.

View larger version (19K): [in a new window]   Figure 3 Correlations between myocardial blood flow (MBF) at rest and during stress and respective heart rate (HR) and pressure rate product (PRP) are shown. Stress correlations are depicted by closed triangles for men and open triangles for women. Resting correlations are depicted by closed circles for men and open circles for women. Correlation coefficients, p values, and equations for each correlation are as shown.