Quantity and function of high density lipoprotein as an indicator of coronary atherosclerosis
Keijiro Saku, MD, PhD, FACPa,
Bo Zhang, MS, PhDa,
Takao Ohta, MD, PhD* and
Kikuo Arakawa, MD, PhD, FACCa
a Department of Internal Medicine and Pathology, Fukuoka University School of Medicine, Fukuoka 814-0180, Japan
* Department of Pediatrics, Ryukyus University School of Medicine, Okinawa 904-2300, Japan
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Figure 1 Relationship between the percentage of patients with angiographically defined coronary atherosclerosis (prevalence of CAD) and FERHDL (in tertiles) according to HDL-C (in tertiles). Open, striped and solid bars represent patients with low, middle and high FERHDL values.
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Figure 2 Model for HDL metabolism in the two-steps reverse cholesterol transport process. The first step is the efflux of cellular free cholesterol to HDL, which is an antiatherogenic step. The second step is the transfer of cholesterol ester from HDL to apo B-containing lipoproteins (LDL and VLDL) via CETP, which may be proatherogenic and is what FERHDL measures.
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