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Therapy with nitroglycerin increases coronary vasoconstriction in response to acetylcholine

^a Division of Cardiology, Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
^* SOCAR Cardiac Research, Toronto, Ontario, Canada

View larger version (15K): [in a new window]   Figure 1 Absolute change in mean luminal diameter of the left anterior descending artery (LAD) coronary artery during intracoronary infusions. Ach–5 and Ach–4 indicate intracoronary acetylcholine infusions, 10–5 and 10–4 mol/liter, respectively. = Nitroglycerin group. = Nonnitroglycerin group. *p < 0.01 versus morning control; p < 0.01 versus afternoon control; p < 0.01 versus morning Ach–4; p < 0.01, GTN group versus non-GTN group.

View larger version (16K): [in a new window]   Figure 2 Percent change in mean luminal diameter of the left anterior descending artery (LAD) coronary artery from baseline, in response to maximal intracoronary acetylcholine infusion (10–4 mol/liter). *p < 0.01 versus morning control; p < 0.01 versus afternoon control; p < 0.05, response in GTN group versus non-GTN group. = Nitroglycerin group. = Nonnitroglycerin group.

View larger version (149K): [in a new window]   Figure 3 Representative coronary angiograms from patients in the non-GTN group (left) and in the GTN group (right). Angiograms were obtained at the time of the morning control (control), during acetycholine 10–4 mol/liter in the morning (AM Ach–4), and acetylcholine 10–4 mol/liter at the time of the afternoon study (PM Ach–4).