Circadian activity of the endogenous fibrinolytic system in stable coronary artery disease: effects of beta-adrenoreceptor blockers and angiotensin-converting enzyme inhibitors
Jeremy W. Sayer, BSc, MB, MRCPa,b,
Charles Gutteridge, MD, FRCPatha,b,
Denise Syndercombe-Court, PhDa,b,
Paul Wilkinson, MB, MRCPa,b and
Adam D. Timmis, MD, FRCPa,b
a Department of Cardiology, Royal Hospitals Trust, Environmental Epidemiology Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom
b Department of Haematology, Royal Hospitals Trust, Environmental Epidemiology Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom
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Figure 1 Circadian variation of PAI-1 and tPA antigens and activities and the effect of treatment with beta-blocker (bisoprolol) and angiotensin-converting enzyme inhibitor (quinapril). Points represent mean values; figures are the standard deviation for each data point. P1 = placebo; BB = beta-blocker; ACEI = angiotensin-converting enzyme inhibitor.
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Figure 2 Variation in ß-TG over 24 h and the effect of treatment with beta-blocker (bisoprolol) and angiotensin-converting enzyme inhibitor (quinapril). Points represent mean values; figures are the standard deviation for each data point. P1 = placebo; BB = beta-blocker; ACEI = angiotensin-converting enzyme inhibitor.
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Figure 3 Twenty-four hour variation of low frequency to high frequency ratio (LF:HF) at baseline (placebo) and after treatment with beta-blocker (bisoprolol) and angiotensin-converting enzyme inhibitor (quinapril). Points represent mean values; figures are the standard deviation for each data point. P1 = placebo; BB = beta-blocker; ACEI = angiotensin-converting enzyme inhibitor.
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Figure 4 Variation in plasma renin over 24 h and the effect of treatment with beta-blocker (bisoprolol) and angiotensin-converting enzyme inhibitor (quinapril). Points represent mean values; figures are the standard deviation for each data point. P1 = placebo; BB = beta-blocker; ACEI = angiotensin-converting enzyme inhibitor.
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