Infarct size reduction by AT1-receptor blockade through a signal cascade of AT2-receptor activation, bradykinin and prostaglandins in pigs
Andreas Jalowy, MDa,
Rainer Schulz, MDa,
Hilmar Dörge, MDa,
Matthias Behrends, MDa and
Gerd Heusch, MD, FESC, FACCa
a Abteilung für Pathophysiologie, Zentrum für Innere Medizin des Universitätsklinikums Essen, Essen, Germany
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Figure 1 Schematic diagram of the four different experimental protocols.
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Figure 2 Effect of candesartan on infarct size. Infarct size in percent of the area at risk was significantly reduced in the pigs receiving candesartan (filled bars) as compared to that of the placebo group (open bars) (p < 0.05 vs. placebo). In the relationships between infarct size and subendocardial blood flow, subendocardial blood flow in the area at risk correlated inversely to infarct size in the placebo (open squares) and the candesartan group (filled squares). Infarct size for any given subendocardial blood flow was significantly reduced in the candesartan group.
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Figure 3 Effect of candesartan on infarct size during AT2-receptor blockade. Infarct size in percent of the area at risk was not different in the pigs receiving PD123319 + candesartan (filled bars) as compared to that of the PD123319 group (open bars). The relationships between infarct size and subendocardial blood flow between the two groups were superimposable.
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Figure 4 Effect of candesartan on infarct size during bradykinin B2-receptor blockade. Infarct size in percent of the area at risk was not different in the pigs receiving HOE140 + candesartan (filled bars) as compared to that of the HOE140-group (open bars). The relationships between infarct size and subendocardial blood flow between the two groups were superimposable.
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Figure 5 Effect of candesartan on infarct size during cyclooxygenase inhibition. Infarct size in percent of the area at risk was not different in the pigs receiving indomethacin + candesartan (filled bars) as compared to that of the indomethacin group (open bars). The relationships between infarct size and subendocardial blood flow between the two groups were superimposable.
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