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Effects of therapy with nifedipine GITS or atenolol on mental stress-induced ischemic left ventricular dysfunction

Thomas C. Andrews, MD, FACC^*, John D. Parker, MD, FACC, Sue Jacobs, PhD, Richard Friedman, PhD, Nancy Cummings, RN^||, Gail MacCallum, BS^¶, Finn Mannting, MD^{# **}, Geoffrey H. Tofler, MD, FACC^** , William Carlson, MD, FACC^{¶ **}, James E. Muller, MD, FACC and Peter H. Stone, MD, FACC^{¶ **}

^* Department of Internal Medicine, Cardiology Division, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Division of Cardiology, Mount Sinai Hospital, University of Toronto, Toronto, Canada
Department of Counseling, University of North Dakota, Grand Forks, North Dakota, USA
Department of Psychiatry, State University of New York at Stony Brook, USA
^|| Department of Surgery, Brigham and Women’s Hospital, Boston, Massachusetts, USA
^¶ Cardiovascular Division/Department of Medicine, Brigham and Women’s Hospital, Boston, USA
^# Department of Nuclear Medicine, Brigham and Women’s Hospital, Boston, USA
^** Harvard Medical School, Boston, USA
Institute for Prevention of Cardiovascular Disease, Deaconess Hospital, Boston, USA
Division of Cardiovascular Medicine, University of Kentucky, Louisville, Kentucky, USA

View larger version (14K): [in a new window]   Figure 1 Change in global ejection fraction: Subjects with a decline of 5% on placebo (n = 5). Boxes indicate mean values, with error bars demonstrating 1 SE unit. EF = left ventricular ejection fraction.

View larger version (19K): [in a new window]   Figure 2 Change in wall-motion score and regional ejection fraction: Comparison of region with largest decrease during placebo phase for all 15 subjects. See text for explanation of wall-motion scoring and Table 2 for absolute values for wall motion and regional EF. Pairwise comparisons are not statistically significant unless otherwise indicated. EF = left ventricular ejection fraction. = placebo; = nifedipine; = atenolol.