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Vascular reactivity is impaired in genetic females taking high-dose androgens

Robyn J. McCredie, BSc^*, Jane A. McCrohon, MB, BS, FRACP^* , Leo Turner, RN, Kaye A. Griffiths, DMU^* , David J. Handelsman, MB, BS, PhD, FRACP and David S. Celermajer, MB, BS, PhD, FRACP^*

^* Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia
The Heart Research Institute, Sydney, Australia
Andrology Unit, Royal Prince Alfred Hospital, Sydney, Australia
Department of Medicine, Sydney University, Sydney, Australia

View larger version (9K): [in a new window]   Figure 1 Flow-mediated and nitroglycerin-induced dilatation in 12 genetic females receiving high-dose androgens (female-to-male transsexuals) and in 12 female control subjects. The y axes refer to percent change in brachial artery diameter. GTN = glyceryl trinitrate (nitroglycerin).