Attenuation-corrected 99mTc-tetrofosmin single-photon emission computed tomography in the detection of viable myocardium: comparison with positron emission tomography using 18F-fluorodeoxyglucose
Ichiro Matsunari, MD*,
Guido Böning*,
Sibylle I. Ziegler, PhD*,
Stephan G. Nekolla, PhD*,
Jens C. Stollfuss, MD*,
Istvan Kosa, MD*,
Edward P. Ficaro, PhD
and
Markus Schwaiger, MD, FACC*
* Nuklearmedizinische Klinik und Poliklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany
Department of Internal Medicine, Division of Nuclear Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA

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Figure 1 An 82-year-old man with three-vessel coronary artery disease. (A) The nonattenuation-corrected 99mTc-tetrofosmin images (left), attenuation-corrected 99mTc-tetrofosmin images (center) and positron emission tomography with 18F-fluorodeoxyglucose (right). (B) Reconstructed transmission images of the patient.
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Figure 2 Bar charts showing the percentage of concordant segments regarding viability between 99mTc-tetrofosmin SPECT and FDG PET (labeled as Concordance), the percentage of 99mTc-tetrofosmin defect segments (<50% of peak activity) within viable segments by FDG PET (labeled as TDV) and the percentage of 99mTc-tetrofosmin uptake segments ( 50% of peak) within nonviable segments (labeled as TUNV) from all 216 segments. Data using a 50% threshold cutoff to define viability by FDG PET are illustrated on the left, and those using a 60% threshold cutoff are on the right. Values are calculated on the patient basis and are expressed as mean ± SD. NC = nonattenuation-corrected image; AC = attenuation-corrected image; n = the number of patients who were eligible for the analysis.
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Figure 3 Bar charts showing the percentage of concordant segments regarding viability between 99mTc-tetrofosmin SPECT and FDG PET (labeled as Concordance), the percentage of 99mTc-tetrofosmin defect segments (<50% of peak activity) within viable segments by FDG PET (labeled as TDV) and the percentage of 99mTc-tetrofosmin uptake segments ( 50% of peak) within nonviable segments (labeled as TUNV) from 166 asynergic segments. Data using a 50% threshold cutoff to define viability by FDG PET are illustrated on the left, and those using a 60% threshold cutoff are on the right. Values are calculated on the patient basis, and are expressed as mean ± SD. NC = nonattenuation-corrected image; AC = attenuation corrected image; n = the number of patients who were eligible for the analysis.
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Figure 4 Bar charts showing the percentage of concordant segments regarding viability between 99mTc-tetrofosmin SPECT and FDG PET (labeled as Concordance), the percentage of 99mTc-tetrofosmin defect segments (<50% of peak activity) within viable segments by FDG PET (labeled as TDV) and the percentage of 99mTc-tetrofosmin uptake segments ( 50% of peak) within nonviable segments (labeled as TUNV) in the anterior-lateral (A) and inferior-septal regions (B). Data using a 50% threshold cutoff to define viability by FDG PET are illustrated on the left, and those using a 60% threshold cutoff are on the right. Values are calculated on the patient basis, and are expressed as mean ± SD. NC = nonattenuation-corrected image; AC = attenuation corrected image; n = the number of patients who were eligible for the analysis.
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Copyright © 1998 by the American College of Cardiology Foundation.