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Hypertrophic remodeling: gender differences in the early response to left ventricular pressure overload

Pamela S. Douglas, MD, FACC^*, Sarah E. Katz, BA^*, Ellen O. Weinberg, PhD^*, Ming Hui Chen, MD^*, Sanford P. Bishop, PhD and Beverly H. Lorell, MD, FACC^*

^* Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA

View larger version (52K): [in a new window]   Figure 1 Examples of M-mode echocardiograms, trans-mitral Doppler flow signals, and LV pressure tracings in anesthetized rats 20 weeks after sham surgery (top), or aortic banding, LVH (bottom). There is increased LV wall thickness in the LVH rats, accompanied by a restrictive mitral filling profile. Note the very diminutive A-wave in the mitral inflow trace at similar heart rate to that seen in the sham animals. Both LV systolic and diastolic pressures are elevated in the LVH rats.

View larger version (11K): [in a new window]   Figure 2 A, Echocardiographic LV mass normalized to body weight at 6 and 20 weeks after aortic banding in male and female rats. While this ratio tended to decrease in male rats, it continued to increase in female rats. B, In vivo LV systolic pressure 6 and 20 weeks after aortic banding in male and female rats. While LV pressure increased in females, it tended to decrease in males. Open squares = female; solid squares = male.