Quantification of mitral regurgitation by automated cardiac output measurement: experimental and clinical validation
Jing Ping Sun, MD, FACCa,
Xing Sheng Yang, MD, PhD, FACCa,
Jian Xin Qin, MDa,
Neil L. Greenberg, PhDa,
Jianhua Zhou, MSa,
Connie J. Vazquez, CCTa,
Brian P. Griffin, MDa,
William J. Stewart, MD, FACCa and
James D. Thomas, MD, FACCa
a Cardiovascular Imaging Center, Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
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Figure 1 Blood flow through left ventricular outflow (left) and inflow (right) tracts. Forward SV is calculated by integrating velocity in space and time throughout systole and diastole, respectively.
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Figure 2 Regression (top) and agreement (bottom) plots comparing CO by ACM and flow meter in animal study.
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Figure 3 Regression (top) and difference (bottom) plots comparing CO by ACM from inflow vs. outflow in normal volunteers without regurgitation.
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Figure 4 Regression (top) and difference (bottom) plots comparing MRV measured by ACM with 2D-PD method in clinical patients.
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Figure 5 Values of regurgitant volume (top) and regurgitant fraction (bottom) (y axis) were compared with the qualitative grading of mitral regurgitant (MR) severity (x axis). Although the mean values were statistically significantly different among grades, considerable overlap is present.
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