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Amiodarone reduces transmural heterogeneity of repolarization in the human heart

Emmanuel Drouin, PhD^*, Gilles Lande, MD and Flavien Charpentier, PhD

^* Department of Neonatology, Centre Hôpitalier Universitaire de Nantes, Nantes, France
Department of Cardiology, Centre Hôpitalier Universitaire de Nantes, Nantes, France
Laboratoire de Physiopathologie et Pharmacologie Cellulaires et Moléculaires INSERM CJF96-01, Centre Hôspitalo-Universitaire de Nantes, Nantes, France

View larger version (15K): [in a new window]   Figure 1 Action potentials recorded under steady-state conditions at PCLs of 1 s (a) and 10 s (b) from epicardial (EPI), deep subepicardial (M cell) and endocardial cells (ENDO) regions of transmural preparations isolated from the left ventricles of AM, NH and HF groups.

View larger version (15K): [in a new window]   Figure 2 Effects of PCL on APD90 in NH (16 preparations), HF (6 preparations) and AM (11 preparations) groups. Epicardial, endocardial and M cells are depicted by circles, squares and triangles, respectively.