Validation of the in vivo intravascular ultrasound measurement of in-stent neointimal hyperplasia volumes
Roxana Mehran, MDa,
Gary S. Mintz, MD, FACCa,
Mun K. Hong, MD, FACCa,
Fermin O. Tio, MD*,
Orville Bramwell, BAa,
Abdel Brahimi, MDa,
Kenneth M. Kent, MD, PhD, FACCa,
Augusto D. Pichard, MD, FACCa,
Lowell F. Satler, MD, FACCa,
Jeffrey J. Popma, MD, FACCa and
Martin B. Leon, MD, FACCa
a Intravascular Ultrasound Imaging and Cardiac Catheterization Laboratories, Washington Hospital Center, Washington, DC, USA
* University of Texas, San Antonio, Texas, USA
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Figure 1 The left-hand panel illustrates the location of the 15 IVUS image slices sampled within each Palmaz–Schatz stent. The middle panel shows a representative IVUS image slice. This slice is duplicated and annotated in the right-hand panel, indicating the stent CSA (outer white circle) and the lumen CSA (inner white circle). The IH CSA was calculated as stent minus lumen CSA.
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Figure 2 The distribution of IH CSA (millimeter squared) measured by IVUS (left-hand panel) and histopathology (right-hand panel) over the length of the stent is shown. Each stent is represented by 15 IVUS and histomorphometric measurements. The proximal end of the stent is on the left (beginning with slice #1 for IVUS and histomorphometry).
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Figure 3 The left-hand panel shows the correlation between the IVUS and histomorphometric measurements of IH volumes (IVUS = 1.3 x histomorphometry –3.0, r = 0.965, p < 0.0001). The right-hand panel shows the Bland and Altmann plot of IVUS-histomorphometric measurement of IH volumes. In all but one case, the IVUS measurement of IH volume was greater than histopathology.
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