This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Cohen, J. L. Articles by Bruns, D. E. Search for Related Content PubMed PubMed Citation Articles by Cohen, J. L. Articles by Bruns, D. E.

Improved left ventricular endocardial border delineation and opacification with OPTISON (FS069), a new echocardiographic contrast agent

Results of a phase III multicenter trial¹

Jerald L. Cohen, MD, FACC^*, Jorge Cheirif, MD, FACC, Douglas S. Segar, MD, FACC, Linda D. Gillam, MD, FACC, John S. Gottdiener, MD, FACC^||, Eva Hausnerova, MD^|| and Denise E. Bruns, BS^¶

^* New Jersey VA Medical Center, East Orange, New Jersey, USA
Ochsner Clinic, New Orleans, Louisiana, USA
Krannert Institute of Cardiology, Indianapolis, Indiana, USA
Hartford Hospital, Hartford, Connecticut, USA
^|| Georgetown University Medical Center, Washington, D.C., USA
^¶ Molecular Biosystems, Inc., San Diego, California, USA

View larger version (67K): [in a new window]   Figure 1 Apical four-chamber views (end-diastole on left, end-systole on right) from a single patient. Top, Before contrast, there is poor LV endocardial border definition. Middle, After injection of 0.22 mg/kg of ALBUNEX, there is minimal improvement in LV endocardial border delineation and faint LV chamber opacification in diastole. In systole, there is almost no contrast effect. Bottom, After injection of 0.5 mL of OPTISON, there is 100% LV chamber opacification and almost complete endocardial border delineation in both diastole and systole.

View larger version (33K): [in a new window]   Figure 2 A, Increase in LV endocardial border length at end-diastole after the two doses of ALBUNEX (ALB) and the four doses of OPTISON (OPT). Open bars, all patients; filled bars, impaired function group. Doses of ALBUNEX in mL/kg, OPTISON in mL. *p < 0.001 for each dose of OPTISON versus each dose of ALBUNEX. B, Increase in LV endocardial border length at end-systole. Abbreviations and symbols as in A.

View larger version (33K): [in a new window]   Figure 3 A, 100% LV opacification at end-diastole. Pts, Patients. Other abbreviations and symbols as in Figure 2A. B, 100% LV opacification at end-systole. Abbreviations and symbols as in Figures 2A and 3A.

View larger version (36K): [in a new window]   Figure 4 A, 67% LV opacification at end-diastole. Abbreviations and symbols as in Figure 2A and 3A. B, 67% LV opacification at end-systole. Abbreviations and symbols as in Figure 2A and 3A.