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Atrial fibrillation is associated with an increased risk for mortality and heart failure progression in patients with asymptomatic and symptomatic left ventricular systolic dysfunction: a retrospective analysis of the SOLVD trials

DanielL Dries, MD, MPH^* , DerekV Exner, MD, BernardJ Gersh, MB, DPhil, ChB, MichaelJ Domanski, MD^*, MyronA Waclawiw, PhD and LynneW Stevenson, MD

^* Clinical Trials Scientific Research Group, The National Heart, Lung and Blood Institute, Bethesda, Maryland, USA
Georgetown University Hospital, Washington, DC, USA
Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, Maryland, USA
The Brigham and Women’s Hospital, Boston, Massachusetts, USA

View larger version (14K): [in a new window]   Figure 1 Kaplan–Meier event-free survival curves for the end point of all-cause mortality comparing those patients with atrial fibrillation (n = 419; solid line) and those patients in sinus rhythm (n = 6,098; broken line) at baseline. Patients with atrial fibrillation had a decreased cumulative survival compared to those with sinus rhythm (log-rank p < 0.001). The number of patients in each group surviving at each 365-day interval is displayed.

View larger version (14K): [in a new window]   Figure 2 Kaplan–Meier event-free survival curves for the end point of deaths due to progressive pump failure. Patients with atrial fibrillation (n = 419; solid line) were more likely than those in sinus rhythm (n = 6,098; broken line) to die from progressive pump failure (log-rank p < 0.001). The number of patients in each group surviving at each 365-day interval is displayed.

View larger version (15K): [in a new window]   Figure 3 Kaplan–Meier event-free survival curves for the composite end point of death or hospitalization for heart failure. Patients with atrial fibrillation (n = 419; solid line) were more likely than those in sinus rhythm (n = 6,098; broken line) to die or be hospitalized for heart failure (log-rank p < 0.001). The number of patients in each group surviving at each 365-day interval is displayed.