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Treating patients with documented atherosclerosis to national cholesterol education program-recommended low-density-lipoprotein cholesterol goals with atorvastatin, fluvastatin, lovastatin and simvastatin

Alan S. Brown, MD^*, Rebecca G. Bakker-Arkema, MS^**, Laurence Yellen, MD, Robert W. Henley, Jr., MD, Richard Guthrie, MD, Cam F. Campbell, MD^||, Michael Koren, MD^¶, William Woo, MD^#, Richard McLain, MS^** and Donald M. Black, MD^**

^* Midwest Heart Research Foundation, Naperville, Illinois, USA
Cardiology Associates Medical Group, San Diego, California, USA
Cardiovascular Associates of Virginia, Richmond, Virginia, USA
St. Paul Heart Clinic, St. Paul, Minnesota, USA
^|| Iowa City Heart Center, Iowa City, Iowa, USA
^¶ Jacksonville Cardiovascular Clinic, Jacksonville, Florida, USA
^# University of Washington Medical School, Seattle, Washington, USA
^** Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Co, Ann Arbor, Michigan, USA

View larger version (19K): [in a new window]   Figure 1 Study design. BID = administered twice daily; QD = administered once daily.

View larger version (34K): [in a new window]   Figure 2 Dose distribution by percentages of patients in each treatment group at week 54 (with the last available observation carried forward). Starting dose: 10 mg atorvastatin and simvastatin; 20 mg fluvastatin and lovastatin. All other monotherapy doses: 20 to 80 mg atorvastatin; 40 mg fluvastatin; 40 to 80 mg lovastatin; 20 to 40 mg simvastatin. Highest dose plus colestipol (up to 20 g/day): 80 mg atorvastatin and lovastatin; 40 mg fluvastatin and simvastatin. White portion = starting dose; gray portion = all other monotherapy doses; black portion = highest dose of reductase inhibitors plus colestipol.

View larger version (20K): [in a new window]   Figure 3 Cumulative percentage of patients reaching the NCEP-recommended LDL cholesterol goal (100 mg/dl). The median dose for each treatment group at week 54 (with the last available observation carried forward) was atorvastatin 20 mg/day, fluvastatin 40 mg/day plus colestipol 20 g/day, lovastatin 80 mg/day and simvastatin 40 mg/day.