Chronic L-arginine treatment increases cardiac cyclic guanosine 5'-monophosphate in rats with aortic stenosis: effects on left ventricular mass and beta-adrenergic contractile reserve
Jozef Bartunek, MD, PhDa,b,c,
Stephen Dempsey, MDa,b,c,
Ellen O. Weinberg, PhDa,b,c,
Nobuhiko Ito, MD, PhDa,b,c,
Minori Tajima, MD, PhDa,b,c,
Susanne Rohrbach, BAa,b,c and
Beverly H. Lorell, MDa,b,c
a Charles A. Dana Research Institute, Beth Israel Deaconess Medical Center, Harvard School, Boston, Massachusetts, USA
b The Harvard-Thorndike Laboratory, Beth Israel Deaconess Medical Center, Harvard School, Boston, Massachusetts, USA
c Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
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Figure 1 Bar graph showing in vivo LVSP measurements. Upper left, in vivo LVSP in control animals. Upper right, in vivo LVSP in rats with aortic stenosis. Lower left, in vivo LV developed pressure/g (LVdevP/g) in control rats. Lower right, In vivo LVdevP/g in rats with aortic stenosis. C = control rats not receiving drugs; C-L-arg = control rats treated with L-arginine; LVH = rats with aortic stenosis not receiving drugs; LVH-L-arg: rats with aortic stenosis treated with L-arginine.
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Figure 2 Graph showing the contractile response to isoproterenol in isolated intact hearts from control animals (left panel) and rats with aortic stenosis (right panel). Abbreviations as in Figure 1.
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Figure 3 Graph showing the contractile response to isoproterenol in isolated control (left panel) and hypertrophied (right panel) myocytes. Abbreviations as in Figure 1.
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Figure 4 Graph showing the relation between isoproterenol infusion and changes in peak systolic intracellular calcium in control (left panel) and hypertrophied (right panel) myocytes. Abbreviations as in Figure 1.
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