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Elevated serum concentrations of cardiac troponin T in acute allograft rejection after human heart transplantation

Thomas J. Dengler, MD^*, Rainer Zimmermann, MD^*, Klaus Braun^*, Margit Müller-Bardorff, MD, J.örg Zehelein, MD^*, Falk-Udo Sack, MD, Philipp A. Schnabel, MD, Wolfgang Kübler, MD^* and Hugo A. Katus, MD

^* Department of Cardiology, University of Heidelberg, Heidelberg, Germany
Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
Department of Pathology, University of Heidelberg, Heidelberg, Germany
Department of Cardiology, University of Lübeck, Lübeck, Germany

View larger version (20K): [in a new window]   Figure 1 Mean troponin T serum concentrations (±SEM [ng/liter]) in separate groups of ISHLT rejection grade versus controls *Significant differences (p < 0.001) versus controls and ISHLT grade 0/1 rejection.

View larger version (39K): [in a new window]   Figure 2 Proportion of positive troponin T determinations (levels above cutoff at 15 ng/ml) in separate groups of rejection grade and controls. *Significant difference versus controls and ISHLT grade 0/1 rejection: p < 0.001; # = ditto, with p < 0.02.

View larger version (28K): [in a new window]   Figure 3 Longitudinal intraindividual analysis of troponin T concentrations (cTNT) and biopsy results. A, Patient EP, male, 48 years old. B, Patient WW, male, 42 years old. Tx, antirejection therapy.