Evaluation of C-reactive protein, an inflammatory marker, and infectious serology as risk factors for coronary artery disease and myocardial infarction
Jeffrey L. Anderson, MD, FACCa,b,
John F. Carlquist, PhDa,b,
Joseph B. Muhlestein, MD, FACCa,b,
Benjamin D. Horne, BSa,b and
Sidney P. Elmer, BSa,b
a University of Utah School of Medicine, Departments of Internal Medicine and Pathology, Salt Lake City, Utah, USA
b LDS Hospital, Salt Lake City, Utah, USA
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Figure 1 CRP serum concentrations (mg/dl) in patients with MI and control subjects (no MI) (upper panel) and patients with CAD and control subjects (no CAD) (lower panel), presented as box (25th to 75th percentile containing median line) and whisker plots (extending to 1.5 box lengths) plus outliers (SPSS). Medians are shown as solid lines, means as dashed lines.
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Figure 2 Odds ratios with 95% confidence intervals for MI (top) or CAD (bottom) in various seropositive versus respective seronegative groups. (Too few patients were positive in the MI group for H. pylori alone to provide data.) CI = confidence interval; C pn = Chlamydia pneumoniae; H pyl = Helicobacter pylori.
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Figure 3 CRP among subgroups with varying numbers of positive infectious serologies (mean mg/dl with SE). Overall linear trend does not achieve significance.
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