Is hospital admission for initiation of antiarrhythmic therapy with sotalol for atrial arrhythmias required?
yield of in-hospital monitoring and prediction of risk for significant arrhythmia complications
Mina K. Chung, MD, FACCa,
Robert A. Schweikert, MDa,
Bruce L. Wilkoff, MD, FACCa,
Mark J. Niebauer, MDa,
Sergio L. Pinski, MDa,
Richard G. Trohman, MD, FACCa,
Gregory A. Kidwell, MD, FACCa,
Fredrick J. Jaeger, DO, FACCa,
Victor A. Morant, MD, FACCa,
Dave P. Miller, MS* and
Patrick J. Tchou, MD, FACCa
a Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
* Ischemia Research and Education Foundation, San Francisco, California, USA

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Figure 1 Time to detection of significant arrhythmia complications (SAC) after initiation of sotalol. The mean time to the earliest detection of clinically significant arrhythmia complications was 2.0 ± 1.9 days. The time to detection of new or increased ventricular arrhythmias was 2.9 ± 1.8 days, significant bradycardia 2.0 ± 1.8 days and excessively prolonged QTc intervals 3.3 ± 3.1 days. The time monitored in the hospital during sotalol therapy after its initiation was 4.7 ± 4.0 days in the total group.
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