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Smooth muscle dysfunction occurs independently of impaired endothelium-dependent dilation in adults at risk of atherosclerosis

Mark R. Adams, MBBS, PhD, FRACP^*, Jacqui Robinson, RN^* , Robyn McCredie, BSc^* , J. Paul Seale, MBBS, PhD, FRACP, Keld E. Sorensen, MD ^||, John E. Deanfield, MB, ChB, FRCP^|| and David S. Celermajer, MBBS, PhD, FRACP^*

^* Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia
Heart Research Institute, Sydney, Australia
Department of Pharmacology, University of Sydney, Sydney, Australia
Department of Cardiology, Skejby Hospital, Aarhus, Denmark
^|| Cardiothoracic Unit, Hospital for Sick Children, Great Ormond Street, London, England, United Kingdom

View larger version (23K): [in a new window]   Figure 1 Scatterplot showing the significant relation between reduced EDD and reduced response to nitroglycerin (NTG). In this series of 800 subjects, the statistically significant relation between EDD and the vasodilator response to NTG is observed independently of the effects of vessel size or traditional vascular risk factors (see Results).