Vitamin C attenuates abnormal vasomotor reactivity in spasm coronary arteries in patients with coronary spastic angina
Kiyotaka Kugiyama, MDa,
Takeshi Motoyama, MDa,
Osamu Hirashima, MDa,
Masamichi Ohgushi, MDa,
Hirofumi Soejima, MDa,
Kenji Misumi, MDa,
Hiroaki Kawano, MDa,
Yuji Miyao, MDa,
Michihiro Yoshimura, MDa,
Hisao Ogawa, MDa,
Toshiyuki Matsumura, MDa,
Seigo Sugiyama, MDa and
Hirofumi Yasue, MDa
a Division of Cardiology, Kumamoto University School of Medicine, Kumamoto, Japan
View larger version (11K):
[in a new window]
|
Figure 1 Schematic representation of infusion protocol. Control = control patients; CSA = patients with coronary spastic angina.
|
|
View larger version (16K):
[in a new window]
|
Figure 2 Percent change in coronary lumen diameter of spasm and control arteries from baseline values at proximal (left) and distal segments (right) in response to ACh.
|
|
View larger version (16K):
[in a new window]
|
Figure 3 Percent changes in coronary lumen diameter of spasm arteries from baseline values at proximal (left) and distal segments (right) in response to ACh with (open circles) or without vitamin C (solid circles) in patients with coronary spastic angina.
|
|
View larger version (13K):
[in a new window]
|
Figure 4 Percent changes in coronary lumen diameter of control arteries from baseline values at proximal (left) and distal segments (right) in response to ACh with (open circles) or without vitamin C (solid circles) in control patients.
|
|
View larger version (19K):
[in a new window]
|
Figure 5 Coronary sinus–arterial difference in TBARS at baseline, during infusion of 50 µg of ACh alone and during infusion of vitamin C plus 50 µg of ACh in patients with coronary spastic angina (CSA, n = 17) and in control patients (Control, n = 23). Data from patients with coronary spastic angina in whom spasm in the LAD and LCx was provoked by infusion of 100 µg, but not 50 µg, of ACh were included in the analysis.
|
|
|
