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J Am Coll Cardiol, 2006; 48:2410-2422, doi:10.1016/j.jacc.2006.07.065 (Published online 28 November 2006).
© 2006 by the American College of Cardiology Foundation
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STATE-OF-THE-ART PAPER

Noninvasive Cardiac Imaging in Patients With Hypertrophic Cardiomyopathy

Sherif F. Nagueh, MD, FACC* and John J. Mahmarian, MD, FACC

Department of Cardiology, The Methodist DeBakey Heart Center, The Methodist Hospital, Houston, Texas

Manuscript received February 2, 2006; revised manuscript received June 28, 2006, accepted July 30, 2006.

* Reprint requests and correspondence: Dr. Sherif F. Nagueh, Department of Cardiology, The Methodist DeBakey Heart Center, 6550 Fannin, Suite 677, Houston, Texas 77030. (Email: snagueh{at}tmh.tmc.edu).

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy and the most common cause of cardiac death in young athletes in the U.S. Noninvasive imaging plays an important role in detecting the disease, understanding its pathophysiology, and selecting as well as guiding appropriate therapy. In this review, we discuss the existing methodology with emphasis on current and emerging clinical applications in patients with HCM.

Abbreviations and Acronyms
  Aa = late diastolic velocity
  AV = atrioventricular
  Ea = early diastolic velocity
  EF = ejection fraction
  HCM = hypertrophic cardiomyopathy
  LA = left atrium/atrial
  LV = left ventricle/ventricular
  LVH = left ventricular hypertrophy
  LVOT = left ventricular outflow tract
  MR = mitral regurgitation
  RV = right ventricle/ventricular
  SAM = systolic anterior motion
  SPECT = single-photon emission computed tomography
  TD = tissue Doppler




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