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J Am Coll Cardiol, 2006; 48:2293-2300, doi:10.1016/j.jacc.2006.07.059 (Published online 9 November 2006).
© 2006 by the American College of Cardiology Foundation
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CLINICAL RESEARCH: HYPERTENSION

A Prospective Study of the Prevalence of Primary Aldosteronism in 1,125 Hypertensive Patients

Gian Paolo Rossi, MD, FACC, FAHA*, Giampaolo Bernini, MD, Chiara Caliumi, MD, Giovambattista Desideri, MD, Bruno Fabris, MD, Claudio Ferri, MD, Chiara Ganzaroli, MD, Gilberta Giacchetti, MD, Claudio Letizia, MD, Mauro Maccario, MD, Francesca Mallamaci, MD, Massimo Mannelli, MD, Mee-Jung Mattarello, MD, Angelica Moretti, MD, Gaetana Palumbo, MD, Gabriele Parenti, MD, Enzo Porteri, MD, Andrea Semplicini, MD, FAHA, Damiano Rizzoni, MD, Ermanno Rossi, MD, Marco Boscaro, MD, Achille Cesare Pessina, MD, PhD, Franco Mantero, MD PAPY Study Investigators

For a list of author affiliations, please see the Appendix

Manuscript received May 10, 2006; revised manuscript received July 13, 2006, accepted July 23, 2006.

* Reprint requests and correspondence: Prof. Gian Paolo Rossi, DMCS Clinica Medica 4, University Hospital, Via Giustiniani 2, 35126 Padova, Italy. (Email: gianpaolo.rossi{at}unipd.it).

OBJECTIVES: We prospectively investigated the prevalence of curable forms of primary aldosteronism (PA) in newly diagnosed hypertensive patients.

BACKGROUND: The prevalence of curable forms of PA is currently unknown, although retrospective data suggest that it is not as low as commonly perceived.

METHODS: Consecutive hypertensive patients referred to 14 hypertension centers underwent a diagnostic protocol composed of measurement of Na+ and K+ in serum and 24-h urine, sitting plasma renin activity, and aldosterone at baseline and after 50 mg captopril. The patients with an aldosterone/renin ratio >40 at baseline, and/or >30 after captopril, and/or a probability of PA (by a logistic discriminant function) ≥50% underwent imaging tests and adrenal vein sampling (AVS) or adrenocortical scintigraphy to identify the underlying adrenal pathology. An aldosterone-producing adenoma (APA) was diagnosed in patients who in addition to excess autonomous aldosterone secretion showed: 1) lateralized aldosterone secretion at AVS or adrenocortical scintigraphy, 2) adenoma at surgery and pathology, and 3) a blood pressure decrease after adrenalectomy. Evidence of excess autonomous aldosterone secretion without such criteria led to a diagnosis of idiopathic hyperaldosteronism (IHA).

RESULTS: A total of 1,180 patients (age 46 ± 12 years) were enrolled; a conclusive diagnosis was attained in 1,125 (95.3%). Of these, 54 (4.8%) had an APA and 72 (6.4%) had an IHA. There were more APA (62.5%) and fewer IHA cases (37.5%) at centers where AVS was available (p = 0.002); the opposite occurred where AVS was unavailable.

CONCLUSIONS: In newly diagnosed hypertensive patients referred to hypertension centers, the prevalence of APA is high (4.8%). The availability of AVS is essential for an accurate identification of the adrenocortical pathologies underlying PA.

Abbreviations and Acronyms
  APA = aldosterone-producing adenoma
  ARR = aldosterone/renin ratio
  AVS = adrenal vein sampling
  CT = computed tomography
  HT = hypertension
  IHA = idiopathic hyperaldosteronism
  LDF = logistic discriminant analysis
  MR = magnetic resonance
  PA = primary aldosteronism
  PRA = plasma renin activity




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Home page
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[Abstract] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Full Text] [PDF]

Home page
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Home page
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Home page
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Home page
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Home page
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[Abstract] [Full Text] [PDF]

Home page
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Therapeutic Advances in Cardiovascular Disease, April 1, 2009; 3(2): 123 - 132.
[Abstract] [PDF]

Home page
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J. Clin. Endocrinol. Metab., April 1, 2009; 94(4): 1125 - 1130.
[Abstract] [Full Text] [PDF]

Home page
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J. Clin. Endocrinol. Metab., March 1, 2009; 94(3): 869 - 875.
[Abstract] [Full Text] [PDF]

Home page
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O Zwermann, Y Suttmann, M Bidlingmaier, F Beuschlein, and M Reincke
Screening for membrane hormone receptor expression in primary aldosteronism
Eur. J. Endocrinol., March 1, 2009; 160(3): 443 - 451.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
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J. Clin. Endocrinol. Metab., February 1, 2009; 94(2): 684 - 690.
[Abstract] [Full Text] [PDF]

Home page
 Cleveland Clinic Journal of MedicineHome page
R. KATAKAM, K. BRUKAMP, and R. R. TOWNSEND
What is the proper workup of a patient with hypertension?
Cleveland Clinic Journal of Medicine, September 1, 2008; 75(9): 663 - 672.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. W. Funder, R. M. Carey, C. Fardella, C. E. Gomez-Sanchez, F. Mantero, M. Stowasser, W. F. Young Jr., and V. M. Montori
Case Detection, Diagnosis, and Treatment of Patients with Primary Aldosteronism: An Endocrine Society Clinical Practice Guideline
J. Clin. Endocrinol. Metab., September 1, 2008; 93(9): 3266 - 3281.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
G. P. Rossi and A. C. Pessina
Response to Delay in the Diagnosis of Conn's Syndrome: A Single-Center Experience Over 30 Years
Hypertension, September 1, 2008; 52(3): e23 - e23.
[Full Text] [PDF]

Home page
 HypertensionHome page
L. M. Ruilope
Aldosterone, Hypertension, and Cardiovascular Disease: An Endless Story
Hypertension, August 1, 2008; 52(2): 207 - 208.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. P. Rossi, A. Belfiore, G. Bernini, B. Fabris, G. Caridi, C. Ferri, G. Giacchetti, C. Letizia, M. Maccario, M. Mannelli, et al.
Body Mass Index Predicts Plasma Aldosterone Concentrations in Overweight-Obese Primary Hypertensive Patients
J. Clin. Endocrinol. Metab., July 1, 2008; 93(7): 2566 - 2571.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
B Rayner
Primary aldosteronism and aldosterone-associated hypertension
J. Clin. Pathol., July 1, 2008; 61(7): 825 - 831.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
G. P. Rossi, M. Bolognesi, D. Rizzoni, T. M. Seccia, A. Piva, E. Porteri, G. A.M. Tiberio, S. M. Giulini, E. Agabiti-Rosei, and A. C. Pessina
Vascular Remodeling and Duration of Hypertension Predict Outcome of Adrenalectomy in Primary Aldosteronism Patients
Hypertension, May 1, 2008; 51(5): 1366 - 1371.
[Abstract] [Full Text] [PDF]

Home page
 Endocr RevHome page
J. M. C. Connell, S. M. MacKenzie, E. M. Freel, R. Fraser, and E. Davies
A Lifetime of Aldosterone Excess: Long-Term Consequences of Altered Regulation of Aldosterone Production for Cardiovascular Function
Endocr. Rev., April 1, 2008; 29(2): 133 - 154.
[Abstract] [Full Text] [PDF]

Home page
 QJMHome page
V.C. Wu, S.C. Chueh, H.W. Chang, W.C. Lin, K.L. Liu, H.Y. Li, Y.H. Lin, K.D. Wu, and B.S. Hsieh
Bilateral aldosterone-producing adenomas: differentiation from bilateral adrenal hyperplasia
QJM, January 1, 2008; 101(1): 13 - 22.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
G. P. Rossi, A. C. Pessina, F. Mantero, and for the Primary Aldosteronism Prevalence in Italy
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[Full Text] [PDF]

Home page
 HypertensionHome page
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Response to More Fuel to the Debate on the "Epidemic of Primary Aldosteronism"
Hypertension, January 1, 2008; 51(1): e3 - e3.
[Full Text] [PDF]

Home page
 HypertensionHome page
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Hypertension, December 1, 2007; 50(6): 1106 - 1113.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
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G-protein-coupled receptors in aldosterone-producing adenomas: a potential cause of hyperaldosteronism
J. Endocrinol., October 1, 2007; 195(1): 39 - 48.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
D. A. Calhoun and N. M. Kaplan
Is There an Unrecognized Epidemic of Primary Aldosteronism? (Pro)
Hypertension, September 1, 2007; 50(3): 447 - 453.
[Full Text] [PDF]

Home page
 HypertensionHome page
N. M. Kaplan and D. A. Calhoun
Is There an Unrecognized Epidemic of Primary Aldosteronism? (Con)
Hypertension, September 1, 2007; 50(3): 454 - 458.
[Full Text] [PDF]

Home page
 HypertensionHome page
G. P. Rossi, A. Belfiore, G. Bernini, G. Desideri, B. Fabris, C. Ferri, G. Giacchetti, C. Letizia, M. Maccario, F. Mallamaci, et al.
Comparison of the Captopril and the Saline Infusion Test for Excluding Aldosterone-Producing Adenoma
Hypertension, August 1, 2007; 50(2): 424 - 431.
[Abstract] [Full Text] [PDF]

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 Eur Heart JHome page
Authors/Task Force Members:, G. Mancia, G. De Backer, A. Dominiczak, R. Cifkova, R. Fagard, G. Germano, G. Grassi, A. M. Heagerty, S. E. Kjeldsen, et al.
2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)
Eur. Heart J., June 11, 2007; (2007) ehm236v1.
[Full Text] [PDF]

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 J Am Coll CardiolHome page
A. N. DeMaria, O. Ben-Yehuda, G. K. Feld, G. S. Ginsburg, B. H. Greenberg, W. Y.W. Lew, J. A.C. Lima, A. S. Maisel, J. Narula, D. J. Sahn, et al.
Highlights of the Year in JACC 2006
J. Am. Coll. Cardiol., January 30, 2007; 49(4): 509 - 527.
[Full Text] [PDF]


 
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