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J Am Coll Cardiol, 1986; 8:436-440
© 1986 by the American College of Cardiology Foundation
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Successful reversal by chelation therapy of congestive cardiomyopathy due to iron overload

PS Rahko, R Salerni, and BF Uretsky

A patient who developed severe iron overload cardiomyopathy is described. Venesection could not be performed because the patient had chronic anemia. Deferoxamine mesylate, a chelating agent, was administered daily for more than 2 years and produced significant improvement in ventricular function which was associated with a biopsy-proven decrease in myocardial iron stores. This is the first reported case in which a severe cardiomyopathy due to iron overload was reversed by chelation therapy alone.


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