|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
|
|
|
|||||||||
|
|||||||||||
|
J Am Coll Cardiol, 1986; 8:327-332 © 1986 by the American College of Cardiology Foundation |
To investigate the influence of lidocaine on the energy requirements for internal defibrillation, lidocaine (n = 8) or saline solution (n = 12) was administered by intravenous infusion to 20 pentobarbital-anesthetized dogs, and the likelihood of successful defibrillation was examined at various shock energy levels before and after treatment. After lidocaine administration to a mean steady state concentration of 5.6 +/- 2.7 micrograms/ml, the mean energy required to achieve 50 and 90% success in defibrillation (E50 and E90) increased by 61.1 +/- 34.1% (mean +/- SD, p less than 0.005) and 47.1 +/- 28.6% (p less than 0.005), respectively. The steady state log lidocaine concentration correlated positively with the observed increase in E50 (r = 0.887, p less than 0.01) over a concentration range from 1.95 to 9.8 micrograms/ml. In a related experiment, lidocaine infusion was administered to five dogs and then abruptly discontinued. At energy levels achieving a mean 90.0 +/- 10.0% success in defibrillation before treatment, only 43.3 +/- 23.4% success was achieved after 60 minutes of the lidocaine infusion (p less than 0.01) at a mean plasma concentration of 8.4 +/- 2.1 micrograms/ml. The percent of successful defibrillations returned to baseline value (92.0 +/- 18.0%, p less than 0.01) after drug washout at a time when mean lidocaine concentration had declined to 1.8 +/- 0.5 microgram/ml. Lidocaine causes a reversible, concentration-dependent increase in the energy requirements for successful defibrillation; recommendations to administer lidocaine to patients with ventricular fibrillation resistant to defibrillation may need to be reviewed.
This article has been cited by other articles:
|
|
 |
|
  J.-q. Zhong, G. Laurent, P. P.-S. So, Xudong Hu, J. K. Hennan, and P. Dorian Effects of Rotigaptide, a Gap Junction Modifier, on Defibrillation Energy and Resuscitation From Cardiac Arrest in Rabbits Journal of Cardiovascular Pharmacology and Therapeutics, March 1, 2007; 12(1): 69 - 77. [Abstract] [PDF]
|
|
|
|
 |
|
 P. Dorian, D. Cass, B. Schwartz, R. Cooper, R. Gelaznikas, and A. Barr Amiodarone as Compared with Lidocaine for Shock-Resistant Ventricular Fibrillation N. Engl. J. Med., March 21, 2002; 346(12): 884 - 890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hamzei, T. Ohara, Y.-H. Kim, M.-H. Lee, O. Voroshilovski, S.-F. Lin, J. N. Weiss, P.-S. Chen, and H. S. Karagueuzian The Role of Approximate Entropy in Predicting Ventricular Defibrillation Threshold Journal of Cardiovascular Pharmacology and Therapeutics, March 1, 2002; 7(1): 45 - 52. [Abstract] [PDF]
|
|
|
|
 |
|
 L.-P. Lai, J.-L. Lin, W.-P. Lien, Y.-Z. Tseng, and S. K. S. Huang Intravenous sotalol decreases transthoracic cardioversion energy requirement for chronic atrial fibrillation in humans: assessment of the electrophysiological effects by biatrial basket electrodes J. Am. Coll. Cardiol., May 1, 2000; 35(6): 1434 - 1441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Ewy and J. P. Ornato Emergency cardiac care: introduction J. Am. Coll. Cardiol., March 15, 2000; 35(4): 825 - 880. [Full Text] [PDF]
|
|
|
|
|
|
P. J. Kudenchuk, L. A. Cobb, M. K. Copass, R. O. Cummins, A. M. Doherty, C. E. Fahrenbruch, A. P. Hallstrom, W. A. Murray, M. Olsufka, and T. Walsh Amiodarone for Resuscitation after Out-of-Hospital Cardiac Arrest Due to Ventricular Fibrillation N. Engl. J. Med., September 16, 1999; 341(12): 871 - 878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A A J Adgey and P W Johnston Approaches to modern management of cardiac arrest Heart, October 1, 1998; 80(4): 397 - 401. [Full Text]
|
|
|
|
|
|
D A Chamberlain Antiarrhythmic drugs in resuscitation Heart, October 1, 1998; 80(4): 408 - 411. [Full Text]
|
|
|
|
 |
|
 Advanced Life Support Working Group of the Europea The 1998 European Resuscitation Council guidelines for adult advanced life support BMJ, June 20, 1998; 316(7148): 1863 - 1869. [Full Text]
|
|
|
|
 |
|
 M. R. Ujhelyi, J. J. Sims, and A. W. Miller High-dose lidocaine does not affect defibrillation efficacy: implications for defibrillation mechanisms Am J Physiol Heart Circ Physiol, April 1, 1998; 274(4): H1113 - H1120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Ujhelyi, M. Schur, T. Frede, M. Gabel, and M. L. Markel Differential Effects of Lidocaine on Defibrillation Threshold With Monophasic Versus Biphasic Shock Waveforms Circulation, September 15, 1995; 92(6): 1644 - 1650. [Abstract] [Full Text]
|
|
|
|
|
|
D. M. Roden Risks and Benefits of Antiarrhythmic Therapy N. Engl. J. Med., September 22, 1994; 331(12): 785 - 791. [Full Text]
|
|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
