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J Am Coll Cardiol, 1986; 7:185-187
© 1986 by the American College of Cardiology Foundation
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Reduced acetylation of procainamide by para-aminobenzoic acid

ES Nylen, AI Cohen, MH Wish, JJ Lima, and JD Finkelstein

Acetylation is the major route of metabolism of many drugs including the antiarrhythmic agent procainamide. Coadministration of para-aminobenzoic acid was observed to decrease the biotransformation of procainamide to N-acetylprocainamide in a patient with rapid acetylation kinetics. In view of the distinct antiarrhythmic and toxic properties of procainamide and N-acetylprocainamide, the observed drug interference may have great clinical relevance in long-term oral antiarrhythmic therapy and in instances where other drugs converge for acetylation.




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Copyright © 1986 by the American College of Cardiology Foundation.