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STATE-OF-THE-ART PAPER

Transcatheter Aortic Valve Implantation for Stenosed and Regurgitant Aortic Valve Bioprostheses

CoreValve for Failed Bioprosthetic Aortic Valve Replacements

Muhammed Z. Khawaja, MBBS^_*,_*, Peter Haworth, MBBS^_*, Azad Ghuran, MBChB, MD^_*, Lorraine Lee, BSE^_*, Adam de Belder, MD^_*, Neville Hutchinson, MD^_*, Uday Trivedi, MBBS^_*, Jean-Claude Laborde, MD and David Hildick-Smith, MD^_*

^_* Sussex Cardiac Centre, Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom
Clinique Pasteur, Toulouse, France

Manuscript received May 13, 2009; revised manuscript received June 22, 2009, accepted June 29, 2009.

^_* Reprint requests and correspondence: Dr. Muhammed Z. Khawaja, Specialist Registrar in Cardiology, Sussex Cardiac Centre, Brighton & Sussex University Hospitals NHS Trust, Eastern Road, Brighton, East Sussex BN2 5BE, United Kingdom (Email: drzeeshan{at}doctors.org.uk).

Transcatheter aortic valve implantation is increasingly being used to treat severe aortic stenosis in patients with high operative risk. In an aging population the incidence of aortic stenosis is rising, and increasing numbers of elderly patients are undergoing aortic valve replacement with bioprosthetic valves. Therefore, there is a corresponding increase in prosthetic degeneration. This presents cardiologists with a cohort of patients for whom the risk of re-do aortic valve surgery is prohibitive. We present the first series of such patients with degenerative bioprosthetic stenosis or regurgitation successfully treated with CoreValve (Medtronic, Luxembourg) implantation.

Key Words: aortic • bioprosthesis • TAVI

Abbreviations and Acronyms   AR = aortic regurgitation   AS = aortic stenosis   AVR = aortic valve replacement   LV = left ventricular/ventricle   TAVI = transcatheter aortic valve implantation

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