Advertisement

Click here for more guidelines.

 
 




CME Topic Collections Past Issues Search Current Issue Home
     

J Am Coll Cardiol, 2009; 54:669-677, doi:10.1016/j.jacc.2009.03.076
© 2009 by the American College of Cardiology Foundation
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (14)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Antoniades, C.
Right arrow Articles by Stefanadis, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Antoniades, C.
Right arrow Articles by Stefanadis, C.
Related Collections
Right arrowRelated Article

STATE-OF-THE-ART PAPER

The CD40/CD40 Ligand System

Linking Inflammation With Atherothrombosis

Charalambos Antoniades, MD*, Constantinos Bakogiannis, MD, Dimitris Tousoulis, MD, PhD, Alexios S. Antonopoulos, MD and Christodoulos Stefanadis, MD

1st Department of Cardiology, University of Athens Medical School, Athens, Greece

Manuscript received December 30, 2008; revised manuscript received March 5, 2009, accepted March 10, 2009.

* Reprint requests and correspondence: Dr. Charalambos Antoniades, 1st Cardiology Department, Athens University Medical School, Hippokration Hospital, Ilias 8, Gerakas Attikis, 153 44, Athens, Greece (Email: antoniades{at}vodafone.net.gr).

The role of CD40/CD40 ligand (CD40L) in atherothrombosis is now widely accepted. However, the exact mechanisms linking the CD40/CD40L system and the soluble form of CD40 ligand (sCD40L) with atherothrombosis are currently a topic of intensive research. CD40L and sCD40L belong to the tumor necrosis factor superfamily, and they are molecules with a dual prothrombotic and proinflammatory role. They are expressed in a variety of tissues such as the immune system (in both B and T cells), the vascular wall, and activated platelets. Soluble CD40L has multiple autocrine, paracrine, and endocrine actions, and it may trigger key mechanisms participating in atherothrombosis. CD40/CD40L may participate in the development of coronary atherosclerosis and the triggering of acute coronary syndromes, while sCD40L seems to have a prognostic role not only in subjects with advanced atherosclerosis but also in the general population. Although conventional cardiovascular medication such as antiplatelet therapy, statins, angiotensin-converting enzyme inhibitors, and many others have been shown to reduce both sCD40L and cardiovascular risk, it is still unclear whether specific treatments targeting the CD40/CD40L system will prove to be beneficial against atherothrombosis in the near future.

Key Words: CD40 • CD40L • atherothrombosis • atherogenesis • inflammation • endothelium

Abbreviations and Acronyms
  ACS = acute coronary syndrome
  AMI = acute myocardial infarction
  CAD = coronary artery disease
  CD40L = CD40 ligand
  EC = endothelial cell
  GP = glycoprotein
  IL = interleukin
  sCD40L = soluble CD40 ligand
  SMC = smooth muscle cell


Related Article

Inside This Issue
J. Am. Coll. Cardiol. 2009 54: A24. [Full Text] [PDF]



This article has been cited by other articles:


Home page
ANGIOLOGYHome page
H. Ge, Y. Zhou, X. Liu, X. Nie, Z. Wang, Y. Guo, W. Chen, and Q. Yang
Relationship Between Plasma Inflammatory Markers and Platelet Aggregation in Patients With Clopidogrel Resistance After Angioplasty
Angiology, January 1, 2012; 63(1): 62 - 66.
[Abstract] [PDF]


Home page
ASH Education BookHome page
Z. S. Kaplan and S. P. Jackson
The Role of Platelets in Atherothrombosis
Hematology, December 1, 2011; 2011(1): 51 - 61.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
C. Goettsch, M. Rauner, K. Sinningen, S. Helas, N. Al-Fakhri, K. Nemeth, C. Hamann, S. Kopprasch, E. Aikawa, S. R. Bornstein, et al.
The Osteoclast-Associated Receptor (OSCAR) Is a Novel Receptor Regulated by Oxidized Low-Density Lipoprotein in Human Endothelial Cells
Endocrinology, December 1, 2011; 152(12): 4915 - 4926.
[Abstract] [Full Text] [PDF]


Home page
CJASNHome page
S. Haller, S. Adlakha, G. Reed, P. Brewster, D. Kennedy, M. W. Burket, W. Colyer, H. Yu, D. Zhang, J. I. Shapiro, et al.
Platelet Activation in Patients with Atherosclerotic Renal Artery Stenosis Undergoing Stent Revascularization
Clin. J. Am. Soc. Nephrol., September 1, 2011; 6(9): 2185 - 2191.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
A. Buil, D.-A. Tregouet, J. C. Souto, N. Saut, M. Germain, M. Rotival, L. Tiret, F. Cambien, M. Lathrop, T. Zeller, et al.
C4BPB/C4BPA is a new susceptibility locus for venous thrombosis with unknown protein S-independent mechanism: results from genome-wide association and gene expression analyses followed by case-control studies
Blood, June 10, 2010; 115(23): 4644 - 4650.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
P. Restituto, I. Colina, J. J. Varo, and N. Varo
Adiponectin diminishes platelet aggregation and sCD40L release. Potential role in the metabolic syndrome
Am J Physiol Endocrinol Metab, May 1, 2010; 298(5): E1072 - E1077.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
J. Rehman
Feeling the Elephant of Cardiovascular Cell Therapy
Circulation, January 19, 2010; 121(2): 197 - 199.
[Full Text] [PDF]


Home page
Oxford Textbook of Interventional CardiologyHome page
R. A. Henderson and L. Lee
Chapter 1 The epidemiology and pathophysiology of coronary artery disease
Oxford Textbook of Interventional Cardiology, January 1, 2010; 1(1): med-9780199569083-chapter - med-9780199569083-chapter.
[Abstract] [Full Text]


Home page
Circ Cardiovasc IntervHome page
M. L. Bilodeau and D. I. Simon
Clopidogrel for the Hot Patient
Circ Cardiovasc Interv, December 1, 2009; 2(6): 495 - 496.
[Full Text] [PDF]



 
  CME Topic Collections Past Issues Search Current Issue Home

Advertisement