This Article Figures Only Full Text Full Text (PDF) Online Appendix Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Tyldum, G. A. Articles by Wisløff, U. Search for Related Content PubMed Articles by Tyldum, G. A. Articles by Wisløff, U. Related Collections Related Article

CLINICAL RESEARCH: ENDOTHELIAL DYSFUNCTION

Endothelial Dysfunction Induced by Post-Prandial Lipemia

Complete Protection Afforded by High-Intensity Aerobic Interval Exercise

Gjertrud Aunet Tyldum, MSc^_*, Inga Ekeberg Schjerve, MSc^_*, Arnt Erik Tjønna, PhD^_*, Idar Kirkeby-Garstad, PhD^_*,, Tomas O. Stølen, MSc^_*, Russell S. Richardson, PhD^_*,,,||,¶ and Ulrik Wisløff, PhD^_*,_*

^_* Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
Department of Cardiothoracic Surgery, St. Olav's University Hospital, Trondheim, Norway
Department of Medicine, University of California, San Diego, La Jolla, California
Department of Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah
^|| Department of Exercise and Sport Science, University of Utah, Salt Lake City, Utah
^¶ Geriatric Research Education and Clinical Center, Salt Lake City VAMC, Salt Lake City, Utah

Manuscript received June 4, 2008; revised manuscript received September 11, 2008, accepted September 12, 2008.

^_* Reprint requests and correspondence: Dr. Ulrik Wisløff, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Medical Technology Research Centre, Olav Kyrres Gate 3, N-7489 Trondheim, Norway (Email: ulrik.wisloff{at}ntnu.no).

Objectives: This study was designed to study the effect of exercise and a high-fat meal (HFM) on endothelial function.

Background: Post-prandial lipemia and exercise oppose each other in terms of cardiovascular risk; however, the mechanism of their interaction is not well understood.

Methods: Endothelial function was assessed by brachial artery flow-mediated dilation (FMD) in 8 healthy men before and after an HFM preceded (16 to 18 h) by rest, a single bout of continuous moderate-intensity exercise (CME), and high-intensity interval exercise (HIIE).

Results: Before the HFM, initial brachial artery diameters were similar in all trials (0.43 ± 0.04 cm), but after the HFM, basal diameter decreased only in the control (0.39 ± 0.03 cm) and CME (0.38 ± 0.04 cm) trials. Before the HFM, FMD/shear was improved by a single bout of CME (+20%, p < 0.01) and HIIE (+45%, p < 0.01; group differences, p < 0.01), with no effect in the control trial. After the HFM (30, 120, and 240 min), FMD decayed to a lesser extent with CME, but in a similar fashion to the control trial. In contrast, FMD in the HIIE trial remained elevated following the exercise despite a clear meal-induced lipemia. Although there were no correlations between vascular function and food-induced markers of cardiovascular risk, antioxidant status was strongly correlated with FMD (r = 0.9, p < 0.001).

Conclusions: These findings reveal a clinically relevant protective effect of acute exercise on the vasculature that is clearly exercise intensity dependent and tightly related to exercise-induced antioxidant capacity. (Endothelial Dysfunction Induced by Postprandial Lipemia; NCT00660491)

Key Words: interval training • endothelial function • high-fat meal

Abbreviations and Acronyms   CME = continuous moderate exercise   FMD = flow-mediated dilation   HFM = high-fat meal   HIIE = high-intensity interval exercise   HRmax = maximal heart rate   VO2max = maximal oxygen uptake

Related Article

Inside This Issue of JACC
J. Am. Coll. Cardiol. 2009 53: A24. [Full Text] [PDF]