This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (6) Citing Articles via Google Scholar Google Scholar Articles by Hunt, S. A. Articles by Haddad, F. Search for Related Content PubMed Articles by Hunt, S. A. Articles by Haddad, F.

STATE-OF-THE-ART PAPER

The Changing Face of Heart Transplantation

Division of Cardiovascular Medicine, Stanford University, Palo Alto, California.

Manuscript received February 26, 2008; revised manuscript received May 14, 2008, accepted May 20, 2008.

^_* Reprint requests and correspondence: Dr. Sharon A. Hunt, Division of Cardiovascular Medicine, Stanford University, 300 Pasteur Drive, Falk CVRB, Stanford Medical Center, Palo Alto, California 94305. (Email: shunt{at}cvmed.stanford.edu).

It has been 40 years since the first human-to-human heart transplant performed in South Africa by Christiaan Barnard in December 1967. This achievement did not come as a surprise to the medical community but was the result of many years of early pioneering experimental work by Alexis Carrel, Frank Mann, Norman Shumway, and Richard Lower. Since then, refinement of donor and recipient selection methods, better donor heart management, and advances in immunosuppression have significantly improved survival. In this article, we hope to give a perspective on the changing face of heart transplantation. Topics that will be covered in this review include the changing patient population as well as recent advances in transplantation immunology, organ preservation, allograft vasculopathy, and immune tolerance.

Key Words: heart transplantation • heart failure • immunology • cardiac surgery • coronary artery disease

Abbreviations and Acronyms   AMR = antibody-mediated rejection   CHD = congenital heart disease   CNI = calcineurin inhibitor   GEP = gene expression profiling   HLA = human leukocyte antigen   ISHLT = International Society for Heart and Lung Transplantation   MCS = mechanical cardiac support   RF = renal failure

This article has been cited by other articles:

				T. Jaarsma, J. M. Beattie, M. Ryder, F. H. Rutten, T. McDonagh, P. Mohacsi, S. A. Murray, T. Grodzicki, I. Bergh, M. Metra, et al. Palliative care in heart failure: a position statement from the palliative care workshop of the Heart Failure Association of the European Society of Cardiology Eur J Heart Fail, May 1, 2009; 11(5): 433 - 443. [Abstract] [Full Text] [PDF]

				R. D. Patten Virtual histology intravascular ultrasound assessing the risk of cardiac allograft vasculopathy. J. Am. Coll. Cardiol., April 14, 2009; 53(15): 1287 - 1288. [Full Text] [PDF]

				J. McMurray, M. Petrie, K. Swedberg, M. Komajda, S. Anker, and R. Gardner CHAPTER 23 Heart Failure ESC Textbook of Cardiovascular Medicine, January 1, 2009; 2(1): med-9780199566990-chapter - med-9780199566990-chapter. [Abstract] [Full Text] [PDF]