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CLINICAL RESEARCH: MYOCARDIAL INFARCTION

Day–Night Variation of Acute Myocardial Infarction in Obstructive Sleep Apnea

Fatima H. Sert Kuniyoshi, PhD^_*,, Arturo Garcia-Touchard, MD^_*, Apoor S. Gami, MD^_*, Abel Romero-Corral, MD, MSc^_*, Christelle van der Walt, RPSGT^_*, Snigdha Pusalavidyasagar, MD^_*, Tomas Kara, MD, PhD, Sean M. Caples, DO, Gregg S. Pressman, MD^¶, Elisardo C. Vasquez, PhD, Francisco Lopez-Jimenez, MD, MSc^_* and Virend K. Somers, MD, PhD, FACC^_*,_*

^_* Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota
Federal University of Espirito Santo, Vitoria, Brazil
International Clinical Research Center Brno and First Department of Internal Medicine—Cardioangiology, St. Anne's University Hospital, Brno, Czech Republic
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic and Foundation, Rochester, Minnesota
^¶ Albert Einstein Medical Center, Philadelphia, Pennsylvania.

Manuscript received March 25, 2008; revised manuscript received April 28, 2008, accepted April 29, 2008.

^_* Reprint requests and correspondence: Dr. Virend K. Somers, Division of Cardiovascular Diseases, 200 First Street SW, Rochester, Minnesota 55905. (Email: somers.virend{at}mayo.edu).

Objectives: This study sought to evaluate the day–night variation of acute myocardial infarction (MI) in patients with obstructive sleep apnea (OSA).

Background: Obstructive sleep apnea has a high prevalence and is characterized by acute nocturnal hemodynamic and neurohormonal abnormalities that may increase the risk of MI during the night.

Methods: We prospectively studied 92 patients with MI for which the time of onset of chest pain was clearly identified. The presence of OSA was determined by overnight polysomnography.

Results: For patients with and without OSA, we compared the frequency of MI during different intervals of the day based on the onset time of chest pain. The groups had similar prevalence of comorbidities. Myocardial infarction occurred between 12 AM and 6 AM in 32% of OSA patients and 7% of non-OSA patients (p = 0.01). The odds of having OSA in those patients whose MI occurred between 12 AM and 6 AM was 6-fold higher than in the remaining 18 h of the day (95% confidence interval: 1.3 to 27.3, p = 0.01). Of all patients having an MI between 12 AM and 6 AM, 91% had OSA.

Conclusions: The diurnal variation in the onset of MI in OSA patients is strikingly different from the diurnal variation in non-OSA patients. Patients with nocturnal onset of MI have a high likelihood of having OSA. These findings suggest that OSA may be a trigger for MI. Patients having nocturnal onset of MI should be evaluated for OSA, and future research should address the effects of OSA therapy for prevention of nocturnal cardiac events.

Key Words: obstructive sleep apnea • myocardial infarction • day–night variation

Abbreviations and Acronyms   AHI = apnea–hypopnea index   BMI = body mass index   BP = blood pressure   MI = myocardial infarction   OSA = obstructive sleep apnea   PSG = polysomnography   SCD = sudden cardiac death

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J. Am. Coll. Cardiol. 2008 52: A33-A34. [Full Text] [PDF]