This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (4) Citing Articles via Google Scholar Google Scholar Articles by Gori, T. Articles by Parker, J. D. Search for Related Content PubMed Articles by Gori, T. Articles by Parker, J. D. Related Collections Related Article

VIEWPOINT

Nitrate-Induced Toxicity and Preconditioning

A Rationale for Reconsidering the Use of These Drugs

Tommaso Gori, MD, PhD^_*,,_* and John D. Parker, MD, FACC

^_* Department of Internal, Cardiovascular, and Geriatric Medicine, University of Siena, Siena, Italy
Medizinische Klinik, University of Mainz, Mainz, Germany
Division of Cardiology, Department of Medicine, Mount Sinai and University Health Network Hospitals, University of Toronto, Toronto, Ontario, Canada.

Manuscript received January 4, 2008; revised manuscript received March 26, 2008, accepted April 3, 2008.

^_* Reprint requests and correspondence: Dr. Tommaso Gori, Department of Internal, Cardiovascular, and Geriatric Medicine, University of Siena, Via Ciacci 42, Siena, Tuscany 53100, Italy. (Email: tommaso.gori{at}utoronto.ca).

Although organic nitrates have been clinically used for more than a century, findings in the last decade have radically challenged our traditional view concerning the mechanism(s) of their clinical effects and implications. While their hemodynamic properties are well known, the knowledge that nitrates possess previously unexpected nonhemodynamic effects is a unique opportunity of which clinicians should be aware but, at the same time, it also provides a rationale to worry about previously unanticipated clinical consequences of long-term treatment with these drugs.

Key Words: nitroglycerin • ischemia • angina • preconditioning

Related Article

Inside This Issue of JACC
J. Am. Coll. Cardiol. 2008 52: A23-A24. [Full Text] [PDF]

This article has been cited by other articles:

				T. Munzel and T. Gori Nebivolol The Somewhat-Different beta-Adrenergic Receptor Blocker. J. Am. Coll. Cardiol., October 13, 2009; 54(16): 1491 - 1499. [Abstract] [Full Text] [PDF]