This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Tanimoto, S. Articles by Serruys, P. W. PubMed Articles by Tanimoto, S. Articles by Serruys, P. W. Related Collections Related Article

CLINICAL RESEARCH: INTERVENTIONAL CARDIOLOGY

Late Stent Recoil of the Bioabsorbable Everolimus-Eluting Coronary Stent and its Relationship With Plaque Morphology

Shuzou Tanimoto, MD^_*, Nico Bruining, PhD^_*,_*, Ron T. van Domburg, PhD^_*, David Rotger, BSc, Petia Radeva, PhD, Jurgen M. Ligthart, BSc^_* and Patrick W. Serruys, MD, PhD, FACC^_*

^_* Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands
Computer Vision Center, Autonomous University of Barcelona, Bellaterra, Spain

Manuscript received June 1, 2007; revised manuscript received August 8, 2008, accepted August 18, 2008.

^_* Reprint requests and correspondence: Dr. Nico Bruining, Erasmus Medical Center, P.O. Box 1738, 3000 DR, Rotterdam, the Netherlands (Email: n.Bruining{at}erasmusmc.nl).

Objectives: This study sought to evaluate late recoil of a novel bioabsorbable everolimus-eluting coronary stent (BVS), which is composed of a poly-L-lactic acid backbone, coated with a bioabsorbable polymer containing everolimus.

Background: Little is known about the mechanical behavior of bioabsorbable polymer stents after deployment in diseased human coronary arteries.

Methods: The study population consisted of 16 patients, who were treated with elective BVS implantation for single de novo native coronary artery lesions and were followed at 6 months. All patients underwent an intravascular ultrasound examination at post-procedure and follow-up. A total of 484 paired cross-sectional areas (CSAs) were acquired and analyzed. Late absolute stent recoil was defined as stent area at post-procedure (X) – stent area at follow-up (Y). Late percent stent recoil was defined as (X – Y)/X x 100. In each CSA, plaque morphology was assessed qualitatively and classified as calcific, fibronecrotic, or fibrocellular plaque.

Results: Late absolute and percent recoil of the BVS was 0.65 ± 1.71 mm² (95% confidence interval [CI]: 0.49 to 0.80 mm²) and 7.60 ± 23.3% (95% CI: 5.52% to 9.68%). Calcified plaques resulted in significantly less late recoil (0.20 ± 1.54 mm² and 1.97 ± 22.2%) than fibronecrotic plaques (1.03 ± 2.12 mm² and 12.4 ± 28.0%, p = 0.001 and p = 0.001, respectively) or fibrocellular plaque (0.74 ± 1.48 mm² and 8.90 ± 19.8%, p = 0.001 and p = 0.001, respectively).

Conclusions: The BVS shrank in size during the follow-up period. The lesion morphology of stented segments might affect the degree of late recoil of the BVS. (ABSORB Everolimus Eluting Coronary Stent System First in Man Clinical Investigation; NCT00300131)

Key Words: bioabsorbable • coronary artery disease • recoil • stents

Abbreviations and Acronyms   AS = acoustic shadowing   BVS = bioabsorbable everolimus-eluting coronary stent   CI = confidence interval   CSA = cross-sectional area   ECG = electrocardiogram   IVUS = intravascular ultrasound   PLLA = poly-L-lactic acid   QCA = quantitative coronary angiography

Related Article

Inside This Issue of JACC
J. Am. Coll. Cardiol. 2008 52: A28. [Full Text] [PDF]