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J Am Coll Cardiol, 2008; 51:843-849, doi:10.1016/j.jacc.2007.10.044
© 2008 by the American College of Cardiology Foundation
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FOCUS ISSUE: ATRIAL FIBRILLATION: CLINICAL RESEARCH: ABLATION THERAPY OF ATRIAL FIBRILLATION

Clinical Outcomes of Catheter Substrate Ablation for High-Risk Patients With Atrial Fibrillation

Koonlawee Nademanee, MD, FACC1,*, Mark C. Schwab, MD, Erol M. Kosar, MD, FACC, Margaret Karwecki, NP, Michael D. Moran, MD, FACC, Nithi Visessook, MD, Anthony Don Michael, MD, FACC and Tachapong Ngarmukos, MD

Pacific Rim Electrophysiology Research Institution, Inglewood, California.

Manuscript received August 22, 2007; revised manuscript received October 10, 2007, accepted October 29, 2007.

* Reprint requests and correspondence: Dr. Koonlawee Nademanee, Pacific Rim Electrophysiology Research Institution, 575 E. Hardy Street, #201, Inglewood, California 90301. (Email: wee{at}pacificrimep.com).

Objectives: The purpose of this study was to determine the long-term clinical outcomes of catheter ablation of atrial fibrillation (AF) substrate for high-risk patients with AF.

Background: The benefits of catheter ablation for high-risk AF patients with respect to mortality and stroke reductions remain unclear.

Methods: We performed AF substrate ablation guided by complex fractionated atrial electrogram (CFAE) mapping in 674 high-risk AF patients. The clinical end points were sinus rhythm (SR), death, stroke, or bleeding. Of these 674 patients, 635 were available for follow-up and made up the study cohort. The patients were relatively old (mean age 67 ± 12 years) and 129 had an ejection fraction (EF) <40%.

Results: After the mean follow-up period of 836 ± 605 days, 517 were in SR (81.4%). There were 15 deaths among the patients who stayed in SR compared with 14 deaths among those who remained in AF (5-year survival rate, 92% vs. 64%, respectively; p < 0.0001). SR was the most important independent favorable parameter for survival (hazard ratio 0.14, 95% confidence interval 0.06 to 0.36, p < 0.0001), whereas old age was unfavorable. Warfarin therapy was discontinued in 434 of the 517 patients in SR post-ablation (84%) whose annual stroke rate was only 0.4% compared with 2% in those with continuing warfarin treatment (p = 0.004).

Conclusions: CFAE-targeted ablation of AF is effective in maintaining SR in selected high-risk AF patients and might allow patients to stop warfarin therapy. SR after AF ablation is a marker of relatively low mortality and stroke risk. Our findings support conducting further randomized studies to determine whether AF ablation is associated with mortality and/or stroke reduction.

Abbreviations and Acronyms
  AF = atrial fibrillation
  CFAE = complex fractionated atrial electrogram
  CI = confidence interval
  CVA = cerebrovascular accident
  EF = ejection fraction
  HR = hazard ratio
  INR = international normalized ratio
  RF = radiofrequency
  SR = sinus rhythm
  TIA = transient ischemic attack


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J. Am. Coll. Cardiol. 2008 51: A23-A24. [Full Text] [PDF]



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