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J Am Coll Cardiol, 2008; 51:690-697, doi:10.1016/j.jacc.2007.10.040
© 2008 by the American College of Cardiology Foundation
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CLINICAL RESEARCH: INTERVENTIONAL CARDIOLOGY

Periprocedural Bleeding and 1-Year Outcome After Percutaneous Coronary Interventions

Appropriateness of Including Bleeding as a Component of a Quadruple End Point

Gjin Ndrepepa, MD*, Peter B. Berger, MD{dagger}, Julinda Mehilli, MD*, Melchior Seyfarth, MD*, Franz-Josef Neumann, MD{ddagger}, Albert Schömig, MD*,§ and Adnan Kastrati, MD*,*

* Deutsches Herzzentrum, Technische Universität, Munich, Germany
{dagger} Geisinger Clinic, Danville, Pennsylvania
{ddagger} Herz-Zentrum, Bad Krozingen, Germany
§ Medizinische Klinik rechts der Isar, Technische Universität, Munich, Germany.

Manuscript received July 31, 2007; revised manuscript received September 21, 2007, accepted October 1, 2007.

* Reprint requests and correspondence: Dr. Adnan Kastrati, Deutsches Herzzentrum, Lazarettstrasse 36, 80636 München, Germany. (Email: kastrati{at}dhm.mhn.de).

Objectives: The aim of the study was to investigate the relationship between bleeding within the 30 days after percutaneous coronary interventions (PCI) and 1-year mortality and to assess the appropriateness of inclusion of the periprocedural bleeding in a quadruple composite end point to assess PCI outcome.

Background: Periprocedural bleeding is one of the most frequent complications of PCI.

Methods: This study included 5,384 patients from 4 randomized placebo-controlled trials on the value of abciximab after pre-treatment with 600 mg of clopidogrel: ISAR-REACT, -SWEET, -SMART-2, and –REACT-2. Bleeding—defined according to the Thrombolysis In Myocardial Infarction criteria—included all bleeding events within 30 days after enrollment. The primary end point was 1-year mortality.

Results: In the 4 trials, within the first 30 days there were 42 deaths (0.8%), 314 myocardial infarctions (MIs) (5.8%), 52 urgent revascularizations (1.0%), and 215 bleeding complications (4.0%). Mortality at 1 year was 3.6% (n = 197). A Cox proportional hazards model revealed that the 30-day occurrence of bleeding (hazard ratio [HR] 2.96, 95% confidence interval [CI] 1.96 to 4.48; p < 0.001), MI (HR 2.29, 95% CI 1.52 to 3.46; p < 0.001) and urgent revascularization (HR 2.49, 95% CI 1.16 to 5.35; p = 0.019) independently predicted 1-year mortality. The c statistic was 0.79 for bleeding, 0.78 for MI, and 0.78 for urgent revascularization, demonstrating a comparable discriminatory power of these adverse events for predicting 1-year mortality.

Conclusions: Our study demonstrates a strong relationship between the 30-day frequency of bleeding and 1-year mortality after PCI and supports the inclusion of periprocedural bleeding in a 30-day quadruple end point for the assessment of outcome after PCI.

Abbreviations and Acronyms
  CI = confidence interval
  HR = hazard ratio
  MI = myocardial infarction
  OR = odds ratio
  PCI = percutaneous coronary intervention


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