This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (9) Citing Articles via Google Scholar Google Scholar Articles by Singh, M. Articles by Holmes, D. R. Search for Related Content PubMed PubMed Citation Articles by Singh, M. Articles by Holmes, D. R., Jr Related Collections Related Article

CLINICAL RESEARCH: INTERVENTIONAL CARDIOLOGY

Mortality Differences Between Men and Women After Percutaneous Coronary Interventions

A 25-Year, Single-Center Experience

Mandeep Singh, MD^_*,_*, Charanjit S. Rihal, MD^_*, Bernard J. Gersh, MB, ChB, DPhil^_*, Veronique L. Roger, MD^_*, Malcolm R. Bell, MD^_*, Ryan J. Lennon, MS, Amir Lerman, MD^_* and David R. Holmes, Jr, MD^_*

^_* Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota
Division of Biostatistics, Mayo Clinic, Rochester, Minnesota.

Manuscript received July 6, 2007; revised manuscript received January 2, 2008, accepted January 14, 2008.

^_* Reprint requests and correspondence: Dr. Mandeep Singh, Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905. (Email: singh.mandeep{at}mayo.edu).

Objectives: Our aim was to examine whether gender-based differences in mortality after percutaneous coronary interventions (PCIs) have changed in the past 25 years.

Background: Women with coronary artery disease have a higher risk of adverse outcomes after PCIs than do men. Recent temporal trends in short-term and long-term mortality in women after PCIs are unknown.

Methods: We performed a retrospective cohort study of 18,885 consecutive, unique patients who underwent PCIs between 1979 and 1995 (early group, n = 7,904, 28% women) and between 1996 and 2004 (recent group, n = 10,981, 31% women). Thirty-day and long-term mortality were compared by gender.

Results: Compared with men, women undergoing PCIs were older and more likely to have diabetes mellitus, hypertension, or hypercholesterolemia. Overall, PCI was successful in 89% of women and 90% of men. In the recent group, 30-day mortality was significantly reduced compared with that in the early group in women (2.9% vs. 4.4%, p = 0.002) and men (2.2% vs. 2.8%, p = 0.04). However, long-term survival was similar between the early and recent groups among both men and women. After adjustment for risk factors, there was no difference between men and women from 1994 onward for either 30-day or long-term outcomes.

Conclusions: The 30-day mortality after PCI in men and women has decreased in the past 25 years. After accounting for baseline risks, no differences in short-term or long-term mortality were observed between men and women.

Abbreviations and Acronyms   ACC = American College of Cardiology   AHA = American Heart Association   PCI = percutaneous coronary intervention

Related Article

What's Good for the Gander Is Now Good for the Goose

Robert F. Wilson and Ganesh Raveendran
J. Am. Coll. Cardiol. 2008 51: 2321-2322. [Full Text] [PDF]

This article has been cited by other articles:

				G. N. Levine, E. R. Bates, J. C. Blankenship, S. R. Bailey, J. A. Bittl, B. Cercek, C. E. Chambers, S. G. Ellis, R. A. Guyton, S. M. Hollenberg, et al. 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions J. Am. Coll. Cardiol., December 6, 2011; 58(24): e44 - e122. [Full Text] [PDF]

				Writing Committee Members, G. N. Levine, E. R. Bates, J. C. Blankenship, S. R. Bailey, J. A. Bittl, B. Cercek, C. E. Chambers, S. G. Ellis, R. A. Guyton, et al. 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions Circulation, December 6, 2011; 124(23): e574 - e651. [Full Text] [PDF]

				K. Goel, R. J. Lennon, R. T. Tilbury, R. W. Squires, and R. J. Thomas Impact of Cardiac Rehabilitation on Mortality and Cardiovascular Events After Percutaneous Coronary Intervention in the Community Circulation, May 31, 2011; 123(21): 2344 - 2352. [Abstract] [Full Text] [PDF]

				S. J. Hoffman, D. R. Holmes Jr, A. A. Rabinstein, C. S. Rihal, B. J. Gersh, R. J. Lennon, R. Bashir, and R. Gulati Trends, Predictors, and Outcomes of Cerebrovascular Events Related to Percutaneous Coronary Intervention: A 16-Year Single-Center Experience J. Am. Coll. Cardiol. Intv., April 1, 2011; 4(4): 415 - 422. [Abstract] [Full Text] [PDF]

				G. W. Mikhail, R. T. Gerber, D. A. Cox, S. G. Ellis, J. M. Lasala, J. A. Ormiston, G. W. Stone, M. A. Turco, A. A. Joshi, D. S. Baim, et al. Influence of Sex on Long-Term Outcomes After Percutaneous Coronary Intervention With the Paclitaxel-Eluting Coronary Stent: Results of the "TAXUS Woman" Analysis J. Am. Coll. Cardiol. Intv., December 1, 2010; 3(12): 1250 - 1259. [Abstract] [Full Text] [PDF]

				R. Mehran and A. S. Kini Sex-Related Outcomes After Drug-Eluting Stent: Should We "Never Mind" or "Mind" the Gap? J. Am. Coll. Cardiol. Intv., December 1, 2010; 3(12): 1260 - 1261. [Full Text] [PDF]

				T. Konecny, K. Somers, M. Orban, Y. Koshino, R. J. Lennon, P. D. Scanlon, and C. S. Rihal Interactions Between COPD and Outcomes After Percutaneous Coronary Intervention Chest, September 1, 2010; 138(3): 621 - 627. [Abstract] [Full Text] [PDF]

				E. D. Peterson, D. Dai, E. R. DeLong, J. M. Brennan, M. Singh, S. V. Rao, R. E. Shaw, M. T. Roe, K. K. L. Ho, L. W. Klein, et al. Contemporary Mortality Risk Prediction for Percutaneous Coronary Intervention: Results From 588,398 Procedures in the National Cardiovascular Data Registry J. Am. Coll. Cardiol., May 4, 2010; 55(18): 1923 - 1932. [Abstract] [Full Text] [PDF]

				A. K. Jacobs The Efficacy of Drug-Eluting Stents in Women: A Window of Opportunity J. Am. Coll. Cardiol. Intv., July 1, 2009; 2(7): 611 - 613. [Full Text] [PDF]

				S. R. Dixon, C. L. Grines, and W. W. O'Neill The Year in Interventional Cardiology J. Am. Coll. Cardiol., June 2, 2009; 53(22): 2080 - 2097. [Full Text] [PDF]

				A. K. Jacobs Coronary Intervention in 2009: Are Women No Different Than Men? Circ Cardiovasc Interv, February 1, 2009; 2(1): 69 - 78. [Full Text] [PDF]

				R. F. Wilson and G. Raveendran What's Good for the Gander Is Now Good for the Goose J. Am. Coll. Cardiol., June 17, 2008; 51(24): 2321 - 2322. [Full Text] [PDF]