This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (2) Citing Articles via Google Scholar Google Scholar Articles by Herrmann, J. Articles by Lerman, A. Search for Related Content PubMed PubMed Citation Articles by Herrmann, J. Articles by Lerman, A.

STATE-OF-THE-ART PAPER

Potential Role of the Ubiquitin-Proteasome System in Atherosclerosis

Aspects of a Protein Quality Disease

Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.

Manuscript received November 7, 2007; revised manuscript received January 28, 2008, accepted February 12, 2008.

^_* Reprint requests and correspondence: Dr. Joerg Herrmann, Department of Internal Medicine, Mayo Clinic Rochester, 200 First Street Southwest, Rochester, Minnesota 55905. (Email: herrmann.joerg{at}mayo.edu).

Misfolded or damaged proteins are recognized intracellularly by protein quality mechanisms. These include chaperones and the ubiquitin-proteasome system, which aim at restoration of protein function and protein removal, respectively. A number of studies have outlined the functional significance of the ubiquitin-proteasome system for the heart and, as of recently, for the vascular system. This review summarizes these recent findings with a focus on atherosclerosis. In particular, this paper reflects on the viewpoint of atherosclerosis as a protein quality disease.

Abbreviations and Acronyms   Abeta = amyloid beta protein   APP = amyloid precursor protein   ER = endoplasmic reticulum   ERAD = endoplasmic reticulum-associated protein degradation   HSP = heat shock protein   LDL = low-density lipoprotein   ROS = reactive oxygen species   TIA = transient ischemic attack   UPS = ubiquitin-proteasome system

This article has been cited by other articles:

				J. Herrmann, L. O. Lerman, and A. Lerman On to the road to degradation: atherosclerosis and the proteasome Cardiovasc Res, November 14, 2009; (2009) cvp333v2. [Abstract] [Full Text] [PDF]

				J. Xu, S. Wang, Y. Wu, P. Song, and M.-H. Zou Tyrosine Nitration of PA700 Activates the 26S Proteasome to Induce Endothelial Dysfunction in Mice With Angiotensin II-Induced Hypertension Hypertension, September 1, 2009; 54(3): 625 - 632. [Abstract] [Full Text] [PDF]

				C. Di Filippo, R. Marfella, and M. D'Amico Possible Dual Role of Ubiquitin-Proteasome System in the Atherosclerotic Plaque Progression J. Am. Coll. Cardiol., October 14, 2008; 52(16): 1350 - 1351. [Full Text] [PDF]

				J. Herrmann, S. M. Soares, L. O. Lerman, and A. Lerman Reply J. Am. Coll. Cardiol., October 14, 2008; 52(16): 1351 - 1351. [Full Text] [PDF]