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STATE-OF-THE-ART PAPER

Potential Role of the Ubiquitin-Proteasome System in Atherosclerosis

Aspects of a Protein Quality Disease

Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.

Manuscript received November 7, 2007; revised manuscript received January 28, 2008, accepted February 12, 2008.

^_* Reprint requests and correspondence: Dr. Joerg Herrmann, Department of Internal Medicine, Mayo Clinic Rochester, 200 First Street Southwest, Rochester, Minnesota 55905. (Email: herrmann.joerg{at}mayo.edu).

Misfolded or damaged proteins are recognized intracellularly by protein quality mechanisms. These include chaperones and the ubiquitin-proteasome system, which aim at restoration of protein function and protein removal, respectively. A number of studies have outlined the functional significance of the ubiquitin-proteasome system for the heart and, as of recently, for the vascular system. This review summarizes these recent findings with a focus on atherosclerosis. In particular, this paper reflects on the viewpoint of atherosclerosis as a protein quality disease.

Abbreviations and Acronyms   Abeta = amyloid beta protein   APP = amyloid precursor protein   ER = endoplasmic reticulum   ERAD = endoplasmic reticulum-associated protein degradation   HSP = heat shock protein   LDL = low-density lipoprotein   ROS = reactive oxygen species   TIA = transient ischemic attack   UPS = ubiquitin-proteasome system

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