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CLINICAL RESEARCH: ATHEROSCLEROSIS

High Serum Cholesteryl Ester Transfer Rates and Small High-Density Lipoproteins Are Associated With Young Age in Patients With Acute Myocardial Infarction

Marianne Zeller, PhD^_*, David Masson, PharmD, PhD^,||, Michel Farnier, MD, PhD, Luc Lorgis, MD, Valérie Deckert, PhD, Jean-Paul Pais de Barros, PhD, Catherine Desrumaux, PhD, Pierre Sicard, MSc^_*, Jacques Grober, PhD, Denis Blache, PhD, Philippe Gambert, MD, PhD^,||, Luc Rochette, PharmD, PhD^_*, Yves Cottin, MD, PhD and Laurent Lagrost, PhD^,_*

^_* Laboratory of Cardiovascular and Experimental Physiopathology and Pharmacology, IFR Santé STIC, Dijon, France
INSERM U866, University of Burgundy, Dijon, France
Point Médical, Dijon, France
Department of Cardiology, University Hospital, Dijon, France
^|| Department of Medical Biochemistry, University Hospital, Dijon, France.

Manuscript received January 12, 2007; revised manuscript received June 8, 2007, accepted June 11, 2007.

^_* Reprint requests and correspondence: Dr. Laurent Lagrost, INSERM U866, Medical School, 7 bld Jeanne d’Arc, 21079 Dijon Cedex, France. (Email: laurent.lagrost{at}u-bourgogne.fr).

Objectives: Our aim was to characterize cholesteryl ester transfer protein (CETP) activity in the early phase of acute myocardial infarction (MI).

Background: Cholesteryl ester transfer protein catalyzes the transfer of cholesteryl esters from high-density lipoprotein (HDL) donors to apolipoprotein B-containing lipoprotein acceptors.

Methods: The CETP concentration, lipid profiles, and the rate of cholesteryl ester transfer (CET) from a tracer dose of radiolabeled HDL toward endogenous lipoproteins were determined within 24 h after symptom onset.

Results: Among 347 patients with first MI, CETP concentration, triglycerides, and non–HDL-cholesterol increased across tertiles of the CET rate, whereas HDL-cholesterol, HDL, and LDL sizes decreased gradually. Among lipoprotein donors and acceptors, the best predictors of the CET rate were HDL2b and non–HDL-cholesterol, respectively. Mean age at first MI was 8.5 years lower in the patients from the highest CET tertile than in those in the lowest CET tertile. Diagonal stratification according to both non–HDL-cholesterol and HDL2b tertiles revealed that patients in the highest CET group were 18 years younger than patients in the lowest CET group. Parameters of the high CETP mass/high non–HDL-cholesterol/low HDL2b triad were independently associated with the CET rate.

Conclusions: In patients with acute MI, high CET rates are characterized by the presence of the high CETP mass/high non–HDL-cholesterol/low HDL2b triad. The association of high CET rates with young age at first MI lends support to a significant contribution of CETP to the accelerated progression of disease among asymptomatic patients.

Abbreviations and Acronyms   apoB = apoliprotein B   BMI = body mass index   CET = cholesteryl ester transfer   CETP = cholesteryl ester transfer protein   CHD = coronary heart disease   HDL = high-density lipoprotein   ICD = International Classification of Diseases   LDL = low-density lipoprotein   MI = myocardial infarction   VLDL = very-low-density lipoproteins

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