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PRECLINICAL STUDY

Ganglionated Plexi Modulate Extrinsic Cardiac Autonomic Nerve Input

Effects on Sinus Rate, Atrioventricular Conduction, Refractoriness, and Inducibility of Atrial Fibrillation

Yinglong Hou, MD^_*, Benjamin J. Scherlag, PhD, Jiaxiong Lin, MD, Ying Zhang, MD, PhD, Zhibing Lu, MD, Kim Truong, DO, Eugene Patterson, PhD, Ralph Lazzara, MD, Warren M. Jackman, MD and Sunny S. Po, MD, PhD^,_*

^_* Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Clinical Medical College of Shandong University, Jinan City, Shandong, China
Cardiac Arrhythmia Research Institute, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Center for American Indian Health Research, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.

Manuscript received October 10, 2006; revised manuscript received February 12, 2007, accepted February 27, 2007.

^_* Reprint requests and correspondence: Dr. Sunny S. Po, 1200 Everett Drive, Room TUH6E103, Oklahoma City, Oklahoma 73104. (Email: sunny-po{at}ouhsc.edu).

Objectives: This study sought to systematically investigate the interactions between the extrinsic and intrinsic cardiac autonomic nervous system (ANS) in modulating electrophysiological properties and atrial fibrillation (AF) initiation.

Background: Systematic ganglionated plexi (GP) ablation to evaluate the extrinsic and intrinsic cardiac ANS relationship has not been detailed.

Methods: The following GP were exposed in 28 dogs: anterior right GP (ARGP) near the sinoatrial node, inferior right ganglionated plexi (IRGP) at the junction of the inferior vena cava and atria, and superior left ganglionated plexi (SLGP) near the junction of left superior pulmonary vein and left pulmonary artery. With unilateral vagosympathetic trunk stimulation (0.6 to 8.0 V, 20 Hz, 0.1 ms in duration), sinus rate (SR), and ventricular rate (VR) during AF were compared before and after sequential ablation of SLGP, ARGP, and IRGP.

Results: The SLGP ablation significantly attenuated the SR and VR slowing responses with right or left vagosympathetic trunk stimulation. Subsequent ARGP ablation produced additional effects on SR slowing but not VR slowing. After SLGP + ARGP ablation, IRGP ablation eliminated VR slowing but did not further attenuate SR slowing with vagosympathetic trunk stimulation. Unilateral right and left vagosympathetic trunk stimulation shortened the effective refractory period and increased AF inducibility of atrium and pulmonary vein near the ARGP and SLGP, respectively. The ARGP ablation eliminated ERP shortening and AF inducibility with right vagosympathetic trunk stimulation, whereas SLGP ablation eliminated ERP shortening but not AF inducibility with left vagosympathetic trunk stimulation.

Conclusions: The GP function as the "integration centers" that modulate the autonomic interactions between the extrinsic and intrinsic cardiac ANS. This interaction is substantially more intricate than previously thought.

Abbreviations and Acronyms   AF = atrial fibrillation   ANS = autonomic nervous system   ARGP = anterior right ganglionated plexi   ERP = effective refractory period   GP = ganglionated plexi   IRGP = inferior right ganglionated plexi   LSPV = left superior pulmonary vein   RSPV = right superior pulmonary vein   SA = sinoatrial   SLGP = superior left ganglionated plexi   SR = sinus rate   VR = ventricular rate

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