Advertisement





Click here for more guidelines.
CME Topic Collections Past Issues Search Current Issue Home
     

J Am Coll Cardiol, 2007; 50:56-60, doi:10.1016/j.jacc.2007.03.030 (Published online 17 June 2007).
© 2007 by the American College of Cardiology Foundation
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
j.jacc.2007.03.030v1
50/1/56    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Walther, T.
Right arrow Articles by Mohr, F. W.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Walther, T.
Right arrow Articles by Mohr, F. W.

PRECLINICAL STUDY

Valve-in-a-Valve Concept for Transcatheter Minimally Invasive Repeat Xenograft Implantation

Thomas Walther, MD, PhD*,*, Volkmar Falk, MD, PhD*, Todd Dewey, MD{ddagger}, Jörg Kempfert, MD*, Fabian Emrich, MD*, Bettina Pfannmüller, MD*, Petra Bröske, DVM*, Michael A. Borger, MD, PhD*, Gerhard Schuler, MD, PhD{dagger}, Michael Mack, MD{ddagger} and Friedrich W. Mohr, MD, PhD*

* Klinik für Herzchirurgie, Leipzig, Germany
{dagger} Kardiologie, Herzzentrum, Universität Leipzig, Leipzig, Germany
{ddagger} Department of Cardiac Surgery, Cardiopulmonary Research Science and Technology Institute, Dallas, Texas.

Manuscript received January 5, 2007; revised manuscript received February 28, 2007, accepted March 5, 2007.

* Reprint requests and correspondence: Dr. Thomas Walther, Universität Leipzig, Herzzentrum, Klinik für Herzchirurgie, Strümpellstrasse 39, 04289 Leipzig, Germany. (Email: walt{at}medizin.uni-leipzig.de).

Objectives: This study sought to evaluate the feasibility of minimally invasive transapical repeat valve-in-a-valve (VinV) implantation.

Background: Reoperative heart valve replacement for degenerated xenografts is associated with an increased surgical risk.

Methods: Conventional Carpentier Edwards porcine aortic (n = 5) and mitral (n = 2) valve prostheses were implanted in 7 pigs. Transapical VinV implantation of a pericardial xenograft fixed within a 23-mm stainless steel, balloon expandable stent (Cribier Edwards, Edwards Lifesciences, Irvine, California) was then performed under fluoroscopic and echocardiographic visualization on the beating heart with ventricular unloading via cardiopulmonary bypass and rapid ventricular pacing.

Results: Valve deployment was successfully performed in all cases. The radiopaque marking within the stent of the conventional aortic or mitral xenograft allowed for optimal positioning of the stent-delivered valve. All valves were firmly positioned without any migration. There were neither paravalvular nor transvalvular leaks, and good hemodynamic function was observed in all cases. All coronary arteries remained patent. Positioning and function were confirmed by autopsy in all animals.

Conclusions: The VinV concept is promising for minimally invasive beating heart repeat aortic or mitral valve replacement, using a stent-fixed sutureless prosthesis.

Abbreviations and Acronyms
  AVR = aortic valve replacement
  CPB = cardiopulmonary bypass
  MVR = mitral valve replacement
  VinV = valve-in-a-valve




This article has been cited by other articles:


Home page
Eur. J. Cardiothorac. Surg.Home page
J. Kempfert, J. Blumenstein, M. W.A. Chu, P. Pritzwald-Stegmann, T. Kobilke, V. Falk, F. W. Mohr, and T. Walther
Minimally invasive off-pump valve-in-a-ring implantation: the atrial transcatheter approach for re-operative mitral valve replacement after failed repair
Eur. J. Cardiothorac. Surg., June 1, 2009; 35(6): 965 - 969.
[Abstract] [Full Text] [PDF]


Home page
J. Thorac. Cardiovasc. Surg.Home page
M. W.A. van Geldorp, W.R. Eric Jamieson, A. P. Kappetein, J. Ye, G. J. Fradet, M. J.C. Eijkemans, G. L. Grunkemeier, A. J.J.C. Bogers, and J. J.M. Takkenberg
Patient outcome after aortic valve replacement with a mechanical or biological prosthesis: Weighing lifetime anticoagulant-related event risk against reoperation risk
J. Thorac. Cardiovasc. Surg., April 1, 2009; 137(4): 881 - 886.
[Abstract] [Full Text] [PDF]


Home page
HeartHome page
M. Thomas
Trans-catheter aortic valve implantation in the United Kingdom: NICE guidance
Heart, April 1, 2009; 95(8): 674 - 675.
[Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
A. Cheung, J. G. Webb, D. R. Wong, J. Ye, J.-B. Masson, R. G. Carere, and S. V. Lichtenstein
Transapical Transcatheter Mitral Valve-in-Valve Implantation in a Human.
Ann. Thorac. Surg., March 1, 2009; 87(3): e18 - e20.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
P. Pibarot and J. G. Dumesnil
Prosthetic Heart Valves: Selection of the Optimal Prosthesis and Long-Term Management
Circulation, February 24, 2009; 119(7): 1034 - 1048.
[Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
T. Walther, J. Kempfert, M. A. Borger, and M. Dehdashtian
Reply
Ann. Thorac. Surg., January 1, 2009; 87(1): 347 - 348.
[Full Text] [PDF]


Home page
Eur Heart JHome page
J. Kempfert, J. M. Blumenstein, M. A. Borger, A. Linke, S. Lehmann, P. Pritzwald-Stegmann, M. W.A. Chu, G. Schuler, V. Falk, F. W. Mohr, et al.
Minimally invasive off-pump valve-in-a-valve implantation: the atrial transcatheter approach for re-operative mitral valve replacement
Eur. Heart J., October 1, 2008; 29(19): 2382 - 2387.
[Abstract] [Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
L. Lozonschi, R. Quaden, N. M. Edwards, J. Cremer, and G. Lutter
Transapical Mitral Valved Stent Implantation
Ann. Thorac. Surg., September 1, 2008; 86(3): 745 - 748.
[Abstract] [Full Text] [PDF]


Home page
ICVTSHome page
J. Grunenfelder, A. Plass, H. Alkadhi, and M. Genoni
Evaluation of biological aortic valve prostheses by dual source computer tomography and anatomic measurements for potential transapical valve-in-valve procedure
Interactive CardioVascular and Thoracic Surgery, April 1, 2008; 7(2): 195 - 200.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll Cardiol IntvHome page
J. G. Webb
Percutaneous Aortic Valve Replacement Will Become a Common Treatment for Aortic Valve Disease
J. Am. Coll. Cardiol. Intv., April 1, 2008; 1(2): 122 - 126.
[Abstract] [Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
T. Walther, J. Kempfert, M. A. Borger, J. Fassl, V. Falk, J. Blumenstein, M. Dehdashtian, G. Schuler, and F. W. Mohr
Human Minimally Invasive Off-Pump Valve-in-a-Valve Implantation
Ann. Thorac. Surg., March 1, 2008; 85(3): 1072 - 1073.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll Cardiol ImgHome page
W. J. Stewart
Imaging the future of transcatheter aortic valve replacement.
J. Am. Coll. Cardiol. Img., January 1, 2008; 1(1): 25 - 28.
[Full Text] [PDF]



 
  CME Topic Collections Past Issues Search Current Issue Home

Advertisement