JACC
HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK
QUICK SEARCH:   [advanced]


     

J Am Coll Cardiol, 1985; 5:840-846
© 1985 by the American College of Cardiology Foundation
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kern, M.
Right arrow Articles by Mudge, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kern, M.
Right arrow Articles by Mudge, G., Jr

Attenuation of coronary vascular resistance by selective alpha 1-adrenergic blockade in patients with coronary artery disease

MJ Kern, JD Horowitz, P Ganz, J Gaspar, WS Colucci, BH Lorell, WH Barry, and GH Mudge Jr

Alpha-adrenergic-mediated coronary vasoconstriction during stress such as cold pressor testing may contribute to myocardial ischemia by increasing coronary vascular resistance in patients with severe coronary artery disease. Nonselective alpha-receptor blockade with phentolamine abolishes both the peripheral and coronary vasoconstriction during cold pressor testing, but causes reflex tachycardia and increased inotropy. To determine the role of selective alpha 1-receptor blockade, the changes in coronary vascular resistance during cold pressor testing were measured in 18 patients with coronary artery disease before and after intravenous administration of 100 mg of trimazosin. Cold pressor testing was performed at a constant paced subanginal heart rate of 95 +/- 5 beats/min (+/- 1 SD). Before trimazosin, cold pressor testing increased mean arterial pressure by 9 +/- 4% (102 +/- 14 to 111 +/- 14 mm Hg, p less than 0.001) with no change in coronary sinus blood flow, but significantly increased coronary vascular resistance by 15 +/- 19% (1.02 +/- 0.46 to 1.15 +/- 0.57 units, p less than 0.05). Five minutes after trimazosin, cold pressor testing increased mean arterial pressure by 6 +/- 5% (p less than 0.001) with a marked attenuation of the increase in coronary vascular resistance (6 +/- 11%, p = NS), which was significantly less than before trimazosin (p less than 0.02). Trimazosin did not increase plasma norepinephrine concentration at rest, suggesting that in the dosage used trimazosin caused selective alpha 1-receptor blockade.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 CirculationHome page
E. Barbato, F. Piscione, J. Bartunek, G. Galasso, P. Cirillo, G. De Luca, G. Iaccarino, B. De Bruyne, M. Chiariello, and W. Wijns
Role of {beta}2 Adrenergic Receptors in Human Atherosclerotic Coronary Arteries
Circulation, January 25, 2005; 111(3): 288 - 294.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
E. Barbato, J. Bartunek, E. Wyffels, W. Wijns, G. R. Heyndrickx, and B. De Bruyne
Effects of intravenous dobutamineon coronary vasomotion in humans
J. Am. Coll. Cardiol., November 5, 2003; 42(9): 1596 - 1601.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
G. Heusch, D. Baumgart, P. Camici, W. Chilian, L. Gregorini, O. Hess, C. Indolfi, and O. Rimoldi
{alpha}-Adrenergic Coronary Vasoconstriction and Myocardial Ischemia in Humans
Circulation, February 15, 2000; 101(6): 689 - 694.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
D. Baumgart, M. Haude, G. Gorge, F. Liu, J. Ge, C. Große-Eggebrecht, R. Erbel, and G. Heusch
Augmented {{alpha}}-Adrenergic Constriction of Atherosclerotic Human Coronary Arteries
Circulation, April 27, 1999; 99(16): 2090 - 2097.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
L. Gregorini, J. Marco, M. Kozakova, C. Palombo, G. B. Anguissola, I. Marco, M. Bernies, B. Cassagneau, A. Distante, I. M. Bossi, et al.
{alpha}-Adrenergic Blockade Improves Recovery of Myocardial Perfusion and Function After Coronary Stenting in Patients With Acute Myocardial Infarction
Circulation, February 2, 1999; 99(4): 482 - 490.
[Abstract] [Full Text] [PDF]


HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK
Copyright © 1985 by the American College of Cardiology Foundation.