|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
|
|
|
|||||||||
|
|||||||||||
|
J Am Coll Cardiol, 1985; 5:832-839 © 1985 by the American College of Cardiology Foundation |
Patients with congestive heart failure have been considered to have augmented sympathetic drive both at rest and during dynamic exercise. The augmentation observed during exercise may be related to the state of near exhaustion experienced by patients with heart failure at relatively low work loads. To compare the response of the sympathetic nervous system to exercise in normal subjects and patients with heart failure when they are working in a comparable physiologic frame of reference, the data for both groups can be expressed as percent peak oxygen consumption achieved (percent peak VO2) rather than as a function of absolute oxygen consumption (VO2). Ten healthy control subjects and 31 patients with chronic clinical class II and III heart failure were studied during upright maximal bicycle exercise. Eighteen of the 31 patients had primary cardiomyopathy and 13 had ischemic cardiomyopathy. The average ejection fraction at rest was 24 +/- 10% (+/- SD) in the group with heart failure. Heart rate, systolic blood pressure, VO2 and plasma norepinephrine levels were measured at rest and throughout exercise. When the data were expressed as a function of percent peak VO2 achieved, patients with heart failure demonstrated a flatter slope (p = 0.004) than normal in the response of plasma norepinephrine to exercise, indicating a relative blunting of sympathetic drive. This was accompanied by attenuated heart rate (p = 0.001) and blood pressure (p less than 0.001) responses. These differences were not apparent when the data are expressed as a function of absolute VO2.(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
|
|
 |
|
  B. Najem, A. Houssiere, A. Pathak, C. Janssen, D. Lemogoum, O. Xhaet, N. Cuylits, and P. van de Borne Acute Cardiovascular and Sympathetic Effects of Nicotine Replacement Therapy Hypertension, June 1, 2006; 47(6): 1162 - 1167. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Duncker, D. B. Haitsma, D. A. Liem, P. D. Verdouw, and D. Merkus Exercise unmasks autonomic dysfunction in swine with a recent myocardial infarction Cardiovasc Res, March 1, 2005; 65(4): 889 - 896. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 ATS/ACCP Statement on Cardiopulmonary Exercise Testing Am. J. Respir. Crit. Care Med., January 15, 2003; 167(2): 211 - 277. [Full Text] [PDF]
|
|
|
|
|
|
D. B Haitsma, D. Bac, N. Raja, F. Boomsma, P. D Verdouw, and D. J Duncker Minimal impairment of myocardial blood flow responses to exercise in the remodeled left ventricle early after myocardial infarction, despite significant hemodynamic and neurohumoral alterations Cardiovasc Res, December 1, 2001; 52(3): 417 - 428. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Kenney, T. I. Musch, and M. L. Weiss Renal sympathetic nerve regulation to heating is altered in rats with heart failure Am J Physiol Heart Circ Physiol, June 1, 2001; 280(6): H2868 - H2875. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Lauer, G. S. Francis, P. M. Okin, F. J. Pashkow, C. E. Snader, and T. H. Marwick Impaired Chronotropic Response to Exercise Stress Testing as a Predictor of Mortality JAMA, February 10, 1999; 281(6): 524 - 529. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. van Veldhuisen, S. Genth-Zotz, J. Brouwer, F. Boomsma, T. Netzer, A. J. Man in 't Veld, Y. M. Pinto, K. I. Lie, and H. J. G. M. Crijns High- versus low-dose ACE inhibition in chronic heart failure: A double-blind, placebo-controlled study of imidapril J. Am. Coll. Cardiol., December 1, 1998; 32(7): 1811 - 1818. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Shoemaker, A. R. Kunselman, D. H. Silber, and L. I. Sinoway Maintained exercise pressor response in heart failure J Appl Physiol, November 1, 1998; 85(5): 1793 - 1799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Lauer, R. Mehta, F. J. Pashkow, P. M. Okin, K. Lee, and T. H. Marwick Association of chronotropic incompetence with echocardiographic ischemia and prognosis J. Am. Coll. Cardiol., November 1, 1998; 32(5): 1280 - 1286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. Silber, G. Sutliff, Q. X. Yang, M. B. Smith, L. I. Sinoway, and U. A. Leuenberger Altered mechanisms of sympathetic activation during rhythmic forearm exercise in heart failure J Appl Physiol, May 1, 1998; 84(5): 1551 - 1559. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Cohen-Solal, P Barnier, F Pessione, P Seknadji, D Logeart, T Laperche, and R Gourgon Comparison of the long term prognostic value of peak exercise oxygen pulse and peak oxygen uptake in patients with chronic heart failure Heart, December 1, 1997; 78(6): 572 - 576. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Rundqvist, G. Eisenhofer, M. Elam, and P. Friberg Attenuated Cardiac Sympathetic Responsiveness During Dynamic Exercise in Patients With Heart Failure Circulation, February 18, 1997; 95(4): 940 - 945. [Abstract] [Full Text]
|
|
|
|
|
|
M. S. Lauer, P. M. Okin, M. G. Larson, J. C. Evans, and D. Levy Impaired Heart Rate Response to Graded Exercise : Prognostic Implications of Chronotropic Incompetence in the Framingham Heart Study Circulation, April 15, 1996; 93(8): 1520 - 1526. [Abstract] [Full Text]
|
|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
