HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: j.jacc.2006.11.021v1 49/7/784    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (2) Citing Articles via Google Scholar Google Scholar Articles by Rozenman, Y. Articles by Parikh, K. H. Search for Related Content PubMed PubMed Citation Articles by Rozenman, Y. Articles by Parikh, K. H.

CLINICAL RESEARCH: HEART FAILURE

Wireless Acoustic Communication With a Miniature Pressure Sensor in the Pulmonary Artery for Disease Surveillance and Therapy of Patients With Congestive Heart Failure

Yoseph Rozenman, MD, FACC^_*,,1,_*, Robert S. Schwartz, MD, FACC^,2, Hetal Shah, MPharm and Keyur H. Parikh, MD, FACC

^_* The Heart Institute, E. Wolfson Medical Center (affiliated with the Sackler Faculty of Medicine Tel-Aviv University), Holon, Israel
Remon Medical Technologies, Caesarea, Israel
Minneapolis Heart Institute and Foundation, Minneapolis, Minnesota
The Heart Care Clinic, Ahmedabad, India.

Manuscript received May 22, 2006; revised manuscript received October 3, 2006, accepted October 9, 2006.

^_* Reprint requests and correspondence: Dr. Yoseph Rozenman, Cardiology Department, The E. Wolfson Medical Center, P.O. Box 5, Holon, Israel, 58100. (Email: rozenman{at}wolfson.health.gov.il).

OBJECTIVES: The purpose of this study was to examine the feasibility of repeated pulmonary artery (PA) pressure determinations using a newly developed acoustic wireless implanted communication system.

BACKGROUND: Congestive heart failure management strategies based on monitored intracardiac hemodynamics in patients receiving the best-available therapy may improve outcome. Although electromagnetic communication requires a large antenna for sufficient energy transfer, acoustic energy readily penetrates deep into the body, uses little energy, and uses small internal transducers for bidirectional operation.

METHODS: A miniature device was developed and implanted using right heart catheterization. The ability to obtain PA pressure from the implant using wireless acoustic communication was examined in 8 pigs and 10 patients with congestive heart failure. Macroscopic and histopathologic examinations were performed at 6 months after implantation. The accuracy of PA pressure measurement was determined by comparison with simultaneous pressures from a Millar catheter.

RESULTS: The device was successfully implanted in the PA using right heart catheterization. There were no implantation or later device-related complications. Pulmonary artery pressure tracings were repeatedly obtained from all implants. Normal reactions to intravascular implant were observed macroscopically and in histologic sections. Standard deviations of the difference between implant and Millar PA diastolic pressure were 1.45 and 1.2 mm Hg (animals and humans, respectively). Data were useful for patient management.

CONCLUSIONS: This pilot study demonstrates, for the first time, that acoustic wireless communication with a miniature implanted sensor is feasible and provides repeated PA pressure measurement. This feat makes possible multiple novel applications for monitoring and therapeutic interventions based on measurements from deeply implanted devices.

Abbreviations and Acronyms   CHF = congestive heart failure   PA = pulmonary artery

This article has been cited by other articles:

				H. E. Verdejo, P. F. Castro, R. Concepcion, M. A. Ferrada, M. A. Alfaro, M. E. Alcaino, C. C. Deck, and R. C. Bourge Comparison of a Radiofrequency-Based Wireless Pressure Sensor to Swan-Ganz Catheter and Echocardiography for Ambulatory Assessment of Pulmonary Artery Pressure in Heart Failure J. Am. Coll. Cardiol., December 18, 2007; 50(25): 2375 - 2382. [Abstract] [Full Text] [PDF]

				W.H. W. Tang and G. S. Francis The Year in Heart Failure J. Am. Coll. Cardiol., December 11, 2007; 50(24): 2344 - 2351. [Full Text] [PDF]