HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: j.jacc.2007.02.059v1 49/25/2379    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (15) Citing Articles via Google Scholar Google Scholar Articles by Chatzizisis, Y. S. Articles by Stone, P. H. Search for Related Content PubMed Articles by Chatzizisis, Y. S. Articles by Stone, P. H.

STATE-OF-THE-ART PAPER

Role of Endothelial Shear Stress in the Natural History of Coronary Atherosclerosis and Vascular Remodeling

Molecular, Cellular, and Vascular Behavior

Yiannis S. Chatzizisis, MD, MSc^_*,, Ahmet Umit Coskun, PhD, Michael Jonas, MD, Elazer R. Edelman, MD, PhD, FACC^_*,,3, Charles L. Feldman, ScD^_*,2 and Peter H. Stone, MD, FACC^_*,1,_*

^_* Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts
Mechanical and Industrial Engineering, Northeastern University, Boston, Massachusetts
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts.

Manuscript received January 2, 2007; revised manuscript received February 22, 2007, accepted February 26, 2007.

^_* Reprint requests and correspondence: Dr. Peter H. Stone, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts. (Email: pstone{at}partners.org).

Although the entire coronary tree is exposed to the atherogenic effect of the systemic risk factors, atherosclerotic lesions form at specific arterial regions, where low and oscillatory endothelial shear stress (ESS) occur. Low ESS modulates endothelial gene expression through complex mechanoreception and mechanotransduction processes, inducing an atherogenic endothelial phenotype and formation of an early atherosclerotic plaque. Each early plaque exhibits an individual natural history of progression, regression, or stabilization, which is dependent not only on the formation and progression of atherosclerosis but also on the vascular remodeling response. Although the pathophysiologic mechanisms involved in the remodeling of the atherosclerotic wall are incompletely understood, the dynamic interplay between local hemodynamic milieu, low ESS in particular, and the biology of the wall is likely to be important. In this review, we explore the molecular, cellular, and vascular processes supporting the role of low ESS in the natural history of coronary atherosclerosis and vascular remodeling and indicate likely mechanisms concerning the different natural history trajectories of individual coronary lesions. Atherosclerotic plaques associated with excessive expansive remodeling evolve to high-risk plaques, because low ESS conditions persist, thereby promoting continued local lipid accumulation, inflammation, oxidative stress, matrix breakdown, and eventually further plaque progression and excessive expansive remodeling. An enhanced understanding of the pathobiologic processes responsible for atherosclerosis and vascular remodeling might allow for early identification of a high-risk coronary plaque and thereby provide a rationale for innovative diagnostic and/or therapeutic strategies for the management of coronary patients and prevention of acute coronary syndromes.

Abbreviations and Acronyms   EC = endothelial cell   ECM = extracellular matrix   eNOS = endothelial nitric oxide synthase   ESS = endothelial shear stress   IEL = internal elastic lamina   IL = interleukin   LDL = low-density lipoprotein cholesterol   MAPK = mitogen-activated protein kinase   MMP = matrix metalloproteinase   NF-B = nuclear factor-kappa B   NO = nitric oxide   ROS = reactive oxygen species   SREBP = sterol regulatory elements binding protein   TCFA = thin cap fibroatheroma   TF = transcription factor   VSMC = vascular smooth muscle cell

This article has been cited by other articles:

				J. D. Humphrey Mechanisms of Arterial Remodeling in Hypertension: Coupled Roles of Wall Shear and Intramural Stress Hypertension, August 1, 2008; 52(2): 195 - 200. [Full Text] [PDF]

				Y. Liu, D. T. Sweet, M. Irani-Tehrani, N. Maeda, and E. Tzima Shc coordinates signals from intercellular junctions and integrins to regulate flow-induced inflammation J. Cell Biol., July 14, 2008; 182(1): 185 - 196. [Abstract] [Full Text] [PDF]

				B De Bruyne and J Sarma Fractional flow reserve: a review: Invasive imaging Heart, July 1, 2008; 94(7): 949 - 959. [Full Text] [PDF]

				J. A. Vita, M. Holbrook, J. Palmisano, S. M. Shenouda, W. B. Chung, N. M. Hamburg, B. R. Eskenazi, L. Joseph, and O. M. Shapira Flow-Induced Arterial Remodeling Relates to Endothelial Function in the Human Forearm Circulation, June 17, 2008; 117(24): 3126 - 3133. [Abstract] [Full Text] [PDF]

				G. P. Kwon, J. L. Schroeder, M. J. Amar, A. T. Remaley, and R. S. Balaban Contribution of Macromolecular Structure to the Retention of Low-Density Lipoprotein at Arterial Branch Points Circulation, June 3, 2008; 117(22): 2919 - 2927. [Abstract] [Full Text] [PDF]

				L. Ai, M. Rouhanizadeh, J. C. Wu, W. Takabe, H. Yu, M. Alavi, R. Li, Y. Chu, J. Miller, D. D. Heistad, et al. Shear stress influences spatial variations in vascular Mn-SOD expression: implication for LDL nitration Am J Physiol Cell Physiol, June 1, 2008; 294(6): C1576 - C1585. [Abstract] [Full Text] [PDF]

				E. R. Mohler III, L. Sarov-Blat, Y. Shi, D. Hamamdzic, A. Zalewski, C. MacPhee, R. Llano, D. Pelchovitz, S. K. Mainigi, H. Osman, et al. Site-Specific Atherogenic Gene Expression Correlates With Subsequent Variable Lesion Development in Coronary and Peripheral Vasculature Arterioscler. Thromb. Vasc. Biol., May 1, 2008; 28(5): 850 - 855. [Abstract] [Full Text] [PDF]

				Y. S. Chatzizisis, M. Jonas, A. U. Coskun, R. Beigel, B. V. Stone, C. Maynard, R. G. Gerrity, W. Daley, C. Rogers, E. R. Edelman, et al. Prediction of the Localization of High-Risk Coronary Atherosclerotic Plaques on the Basis of Low Endothelial Shear Stress: An Intravascular Ultrasound and Histopathology Natural History Study Circulation, February 26, 2008; 117(8): 993 - 1002. [Abstract] [Full Text] [PDF]

				B. De Bruyne and E. Barbato Drug-Eluting Stent Implantation: Technique Matters, More Than Ever J. Am. Coll. Cardiol. Intv., February 1, 2008; 1(1): 32 - 33. [Full Text] [PDF]

				H. Kaneda Complex Roles of Endothelial Shear Stress in Vascular Remodeling Response J. Am. Coll. Cardiol., November 27, 2007; 50(22): 2171 - 2171. [Full Text] [PDF]

				Y. Chatzizisis, A. U. Coskun, M. Jonas, E. R. Edelman, C. L. Feldman, and P. H. Stone Reply J. Am. Coll. Cardiol., November 27, 2007; 50(22): 2171 - 2172. [Full Text] [PDF]

				J. P. De Bono and K. M. Channon Endothelial Cell Tetrahydrobiopterin: Going With the Flow Circ. Res., October 12, 2007; 101(8): 752 - 754. [Full Text] [PDF]