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J Am Coll Cardiol, 2007; 49:2102-2104, doi:10.1016/j.jacc.2007.02.042 (Published online 11 May 2007).
© 2007 by the American College of Cardiology Foundation
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FOCUS ISSUE: PLAQUE NEOVASCULARIZATION, HEMORRHAGE, AND VULNERABILITY: COMMENTARY

Atherosclerosis in the Back Yard

Joerg Herrmann, MD and Amir Lerman, MD*

Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota.

Manuscript received January 24, 2007; accepted February 19, 2007.

* Reprint requests and correspondence: Dr. Amir Lerman, Division of Cardiovascular Diseases, Mayo Clinic Rochester, 200 First Street SW, Rochester, Minnesota 55905. (Email: lerman.amir{at}mayo.edu).

The phenomenon of neovascularization in atherosclerosis has been widely recognized through "the eyes of novel imaging techniques" in recent years. Oxidative stress, inflammation, and hypoxia have been implied as the underlying mechanisms. The pathophysiologic consequences and therapeutic implications of this neovascularization process for atherosclerosis have, however, remained challenging and controversial. In the current focus issue of the Journal, 4 articles and this commentary are devoted to this topic.

Abbreviations and Acronyms
  RBC = red blood cell
  VEGF = vascular endothelial growth factor


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Copyright © 2007 by the American College of Cardiology Foundation.