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CLINICAL RESEARCH: CARDIAC IMAGING

Diagnostic Accuracy of Multidetector Computed Tomography Coronary Angiography in Patients With Dilated Cardiomyopathy

Centro Cardiologico Monzino, IRCCS, Institute of Cardiology, University of Milan, Milan, Italy.

Manuscript received September 29, 2006; revised manuscript received December 15, 2006, accepted January 1, 2007.

^_* Reprint requests and correspondence: Dr. Daniele Andreini, Via Parea 4, 20138 Milan, Italy. (Email: daniele.andreini{at}ccfm.it).

Objectives: The purpose of this work was to assess the safety, feasibility, and diagnostic accuracy of multidetector computed tomography (MDCT) in dilated cardiomyopathy (DCM) of unknown etiology.

Background: Multidetector computed tomography is an appropriate noninvasive tool for coronary artery disease (CAD) detection, particularly in patients with low probability of the disease, such as patients with DCM of unknown origin.

Methods: We studied 61 unknown origin DCM patients (ejection fraction: 33.9 ± 8.6%, group 1) and 139 patients with normal cardiac function with indications for coronary angiography (group 2, control population). All underwent coronary MDCT and angiography. Multidetector computed tomography images were acquired by light speed 16-slice computed tomography. The degree of stenosis was estimated in 15 coronary artery segments according to the American Heart Association model.

Results: In group 1, no MDCT-related complications were found, while 10 complications were associated with conventional angiography (p = 0.001). Overall feasibility of coronary artery visualization was 97.2% (863 of 888 segments). The most frequent cause of artifacts was interference from a hypertrophic cardiac venous system (10 artifacts, 40%). In group 2, overall feasibility was 96.1% (p = NS vs. group 1). In group 1, all cases with normal (44 cases) or pathological (17 cases) coronary arteries by conventional coronary angiography were correctly detected by MDCT, with, in 1 case, disparity of stenosis severity. In group 1, sensitivity, specificity, and positive and negative predictive values of MDCT for the identification of >50% stenosis were 99%, 96.2%, 81.2%, and 99.8%, respectively. In group 2, sensitivity and negative predictive values were lower than in group 1 (86.1% vs. 99% and 96.4% vs. 99.8%, respectively); specificity (96.4%) and positive predictive value (86.1%) were not significantly different versus group 1.

Conclusions: Multidetector computed tomography is feasible, safe, and accurate for identification of idiopathic versus ischemic DCM, and may represent an alternative to coronary angiography.

Abbreviations and Acronyms   CAD = coronary artery disease   CT = computed tomography   DCM = dilated cardiomyopathy   ICA = invasive coronary angiography   MDCT = multidetector computed tomography

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